Preparation, Evaluation and Characterization of Antihypertensive Drug for Matrix Transdermal Patches

Abstract

Nicorandil belongs to the elegance of potassium channel activators, which exert their transfer through arterio-dilating and vasodilating properties and represents a unique form of compound for use withinside the treatment of angina pectoris. It has a short ½ of existence and the usual oral dosage routine is 5-40mg taken to 4 times a day. V G Jamakandi et al., employed solvent casting technique to formulate HPMC patches containing specific grades of HPMC polymer (6 cps, 15 cps and K4M) as matrix base, polyethylene glycol as plasticizer and DMSO as penetration enhancer. Prepared matrix type patches were evaluated for their physicochemical characterization followed through in-vitro and ex-vivo studies on porcine ear pores and skin. The quit end result shows transdermal patch with 6 cps 2% w/v HPMC,30% w/v PEG 400 and 6%w/v DMSO as a penetration enhancer showed a maximum release (44.7%) and it offers least resistance for the drug movement due to its immoderate hydrophilic nature and immoderate water permeability value to water. Transdermal Drug Delivery System is the system in which the delivery of the active ingredients of the drug occurs by the means of skin. Skin is an effective medium from which absorption of the drug takes place and enters the circulatory system. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin. The patches have been proved effective because of its large advantages over other controlled drug delivery systems .