Synthesis Characterization of 1,3,4 Oxadiazole and Its Pharmacological Activity
DOI:
https://doi.org/10.32628/IJSRST229371Keywords:
1,3.4- Oxadiazole, heterocyclic compounds, alkylation, sonicationAbstract
We report the synthesis as well as biological assessment of 1,3,4-oxadiazole substituted 24 derivatives as novel, potential antibacterial agents. The structures of the newly synthesized derivative was established by the combined practice of UV, IR, 1H NMR, 13C NMR, as well as mass spectrometry. Further those synthesized derivative was subjected to antibacterial activity against all the selected microbial strains in comparison with amoxicillin and cefixime. The antibacterial activity of synthesized derivatives was connected with their physicochemical as well as structural properties by QSAR analysis using computer assisted multiple regression analysis and four sound predictive models were generated with good, and Fischer statistic. The derivatives with powerful antibacterial activity were subjected to molecular docking studies to investigate the interactions between the active derivatives and amino acid residues existing in the active site of peptide deformylase to estimate their antibacterial potential as peptide deformylase inhibitor.
References
- Bala S, Kamboj S, Kajal A, Saini V, Prasad D N. 1, 3, 4-oxadiazole derivatives: synthesis, characterization, antimicrobial potential, and computational studies. BioMed research international. 2014; 1: 1-18.
- Pangal A, Shaikh J A. Various pharmacological aspects of 2, 5-disubstituted 1, 3, 4- oxadiazole derivatives: a review. Research Journal of Chemical Sciences. 2011; 3(2): 248-255.
- Glomb T, Swiatek P. Antimicrobial activity of 1, 3, 4-Oxadiazole Derivatives. International Journal of Molecular Sciences. 2021; 22: 6979.
- Sengupta P, Dash D K, Yeligar V C. Evaluation of anticancer activity of some 1, 3, 4- oxadiazole derivatives. Indian Journal of Chemistry. 2008; 47: 460-462.
- Mohan C D, Anilkumar N C, Rangappa S, Shanmugam M K, Mishra S, Chinnathambi A, Alharbi S A, Bhattacharjee A, Sethi G, Kumar A P, Rangappa K S. Novel 1, 3, 4- oxadiazole induces anticancer activity by targeting NF-κB in hepatocellular carcinoma cells. Frontiers in oncology. 2018; 19: 8-42.
- Baijika P, Akash marathakam, Midhula C and Shadihasaheed K. synthesis and biological activities of 1, 3, 4-oxadiazole derivatives: a review of literature. International journal of advance research. 2018; 6(1): 1114-1122.
- Chikhalia K H, Vashi D B, Patel M J. Synthesis of a novel class of some 1, 3, 4- oxadiazole derivatives as antimicrobial agents. Journal of Enzyme Inhibition and Medicinal Chemistry. 2009; 23(3): 617-22.
- Asif M. A mini review on biological potential of 1, 3, 4-oxadiazole derivatives. International Journal of Pharmaceutical Chemistry and Analysis. 2019; 5(4): 179-187.
- Kaur R, Kaur P. Synthesis and pharmacological activities of 1, 3, 4-oxadiazole derivatives: a review. European journal of biomedical. 2018; 5(6): 865-877.
- Amer H H, Ali O M, Salama A A, El-gendy M S, Houssin O K. Synthesis of some new 1, 3, 4-oxadiazole derivatives bearing sugars and α-aminophosphonate derived from 4- nitrophenol as anticancer agents. National Journal of Physiology, Pharmacy and Pharmacology. 2018; 8(9): 1275-1286.
- Rajput M D, Yadav A R. Green Chemistry Approach for Synthesis of Some 1, 3, 4- Oxadiazole Derivatives as Potent Antimalarial Agents. Journal of university of shanghai for science and technology. 2020; 22(11): 1854-1869.
- Jagtap N, Yadav A, Mohite S. Synthesis. Molecular Docking Studies and Anticancer Activity of 1, 3, 4-Oxadiazole-3 (2H)-thione Derivatives. Journal of University of Shanghai for Science and Technology. 2020; 22(11): 535-550.
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