An Overview on Oxidative Stress in Diabetes Mellitus

Authors

  • Jagroop Singh  Ph.D (Biochemistry) Scholar, Desh Bhagat University, Mandi Gobindgarh, Punjab, India
  • Dr. Sukhraj Kaur  Professor and Head, Department of Biochemistry, Govt Medical College Amritsar Punjab
  • Dr. Manpreet Kaur Verma  Assistant Professor, Department of Chemistry, Desh Bhagat University, Gobindgarh, Punjab, India
  • Manjinder Kaur  Nursing Officer, Government Medical college Amritsar Punjab, India

DOI:

https://doi.org/10.32628/IJSRST229393

Keywords:

Diabetes Mellitus, Oxidative Stress, Biomarkers

Abstract

Human body is continuously exposed to different types of agents that results in the production of reactive species called as free radicals (ROS/RNS) which by the transfer of their free unpaired electron causes the oxidation of cellular machinery. In order to encounter the deleterious effects of such species, body has got endogenous antioxidant systems or it obtains exogenous antioxidants from diet that neutralizes such species and keeps the homeostasis of body. Any imbalance between the RS and antioxidants leads to produce a condition known as ‘‘oxidative stress’’ that results in the development of pathological condition among which one is diabetes. Most of the studies reveal the inference of oxidative stress in diabetes pathogenesis by the alteration in enzymatic systems, lipid peroxidation, impaired Glutathione metabolism and decreased Vitamin C levels. Lipids, proteins, DNA damage, Glutathione, catalane and superoxide dismutase are various biomarkers of oxidative stress in diabetes mellitus. Oxidative stress induced complications of diabetes may include stroke, neuropathy, retinopathy and nephropathy. The basic aim of this review was to summarize the basics of oxidative stress in diabetes mellitus

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International Journal of Scientific Research in Science and Technology

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Published

2022-06-30

Issue

Volume 9, Issue 3, May-June-2022

Section

Research Articles

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[1]
Jagroop Singh, Dr. Sukhraj Kaur, Dr. Manpreet Kaur Verma, Manjinder Kaur "An Overview on Oxidative Stress in Diabetes Mellitus" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 9, Issue 3, pp.444-448, May-June-2022. Available at doi : https://doi.org/10.32628/IJSRST229393