An Overview on Oxidative Stress in Diabetes Mellitus

Authors

  • Parvaiz Ahmad Dar  Department of Biochemistry, University of Kashmir, Jammu and Kashmir, India
  • Mohd Ishaq Dar  Cancer Pharmacology Division, IIIM, Jammu, Jammu and Kashmir, India
  • Mashooq Ahmad Dar  Department of Biochemistry, University of Kashmir, Jammu and Kashmir, India
  • Aarif Ali  Department of Biochemistry, University of Kashmir, Jammu and Kashmir, India
  • Shahnawaz Ahmad Wani  Department of Biochemistry, Jamia Millia Islamia, New Delhi, India

Keywords:

Diabetes Mellitus, Oxidative Stress, Biomarkers

Abstract

Diabetes mellitus is a complicated metabolic disorder of carbohydrate metabolism that has gravely affected the human health and quality of life. It is a global health crisis, which has been persistently affecting the humanity, irrespective of the socioeconomic profile and geographic location of the population. According to an estimate, every five seconds one person is detected with diabetes somewhere in the world, while someone dies of it every ten seconds. Oxidative stress plays a major role in the onset and progression of diabetes. Many of the common risk factors, such as increased age, unhealthy eating habits and obesity, all contribute to an oxidative environment that may change insulin sensitivity either by increasing insulin resistance or impairing glucose tolerance. The mechanisms by which alteration in insulin sensitivity occurs are often multifactorial and quite complex, involving multiple cell signaling pathways. A common outcome of diabetes is hyperglycemia, which in turn contributes to the progression and disturbance of an overall cellular oxidative status. Oxidative stress seems to be a significant causative agent both in onset as well as progression of diseases.

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International Journal of Scientific Research in Science and Technology

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Published

2017-12-31

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Volume 3, Issue 8, November-December-2017

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Research Articles

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How to Cite

[1]
Parvaiz Ahmad Dar, Mohd Ishaq Dar, Mashooq Ahmad Dar, Aarif Ali, Shahnawaz Ahmad Wani "An Overview on Oxidative Stress in Diabetes Mellitus" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 3, Issue 8, pp.731-734, November-December-2017.