Synthesis, Characterization and Biological Activity of Metal Complexes of Novel Schiff Base Bearing Imidazole Moeity

Authors

  • Jalpa G. Gadara  Department of Chemistry, H. & H. B. Kotak Institute of Science, Yagnik Road, Rajkot, Gujarat, India
  • Manhar V. Parsania  Department of Chemistry, Shri M. M. Science College, Anand Nagar, Morbi, Gujarat, India

Keywords:

4H-imidazol-4-one, Schiff base, Metal complexes, Anti-bacterial activity, Anti-fungal activity

Abstract

Synthesis of novel metal complexes by reaction of 3-((E)-benzylidene)-amino)-5-(3,4-dimethoxybenzylidene)-2-phenyl-3,5-dihydro-4H-imidazol-4-one with different metal chlorides is accomplished. All the newly synthesized metal complexes were characterized and studied using various techniques viz. ESI Mass, IR, UV and Elemental Analyses. Antimicrobial activity of all metal complexes was evaluated against selected strains of bacteria and fungi.

References

  1. G. Ya, H. Dai-Chuan, L. Chang, S. Zi-Long, Z. Ming-Zhi, Streptochlorin analogues as potential antifungal agents: Design, synthesis, antifungal activity and molecular docking study. Bioorganic & Medicinal Chemistry, 35 (2021) 116073-77. https://doi.org/10.1016/j.bmc.2021.116073
  2. A. Verma, S. Joshi, A. Singh, Imidazole: Having Versatile Biological Activities. Journal of Chemistry (2013) 329412. http://dx.doi.org/10.1155/2013/329412
  3. A. Suaad, J. Briody, V. Fontecha, V. McKee, Synthesis, structure and anti-fungal activity of dimeric Ag(I) complexes containing bis-imidazole ligands. Polyhedron, 23 (2004) 1249-1255. https://doi.org/10.1016/j.poly.2004.02.006
  4. L. Chai, L. Zhou, K-Y Zhang , H-S Zhang, Structural characterizations, spectroscopic, electrochemical properties, and antibacterial activities of copper (II) and cobalt (II) complexes containing imidazole ring. Appl. Organometal. Chem., 32 (2018) e4576. https://doi.org/10.1002/aoc.4576
  5. A. ȘerbanGâz, A. FranciscBoda, R. Rahela Pop, Imidazole Derivatives and their Antibacterial Activity-A Mini-Review. Mini-Reviews in Medicinal Chemistry, 21 (2021) 1380-1392. https://dx.doi.org/10.2174/1389557520999201209213648
  6. A. J. K. Atia, Synthesis and Antibacterial Activities of New Metronidazole and Imidazole Derivatives. Molecules. 14 (2009) 2431-2446. https://doi.org/10.3390/molecules14072431
  7. M. Ismael, A. Abdou, A. M. Abdel-Mawgoud, Synthesis, Characterization, Modeling, and Antimicrobial Activity of FeIII, CoII, NiII, CuII, and ZnII Complexes Based on Tri-substituted Imidazole Ligand. Z. Anorg. Allg. Chem., 644 (2018) 1203-1214. https://doi.org/10.1002/zaac.201800230
  8. A. Valls, J. J. Andreu, E. Falomir, S. V. Luis, E. Atrián-Blasco, S. G. Mitchell, B. Altava, Imidazole and Imidazolium Antibacterial Drugs Derived from Amino Acids. Pharmaceuticals. 13 (2020) 482. https://doi.org/10.3390/ph13120482
  9. A. M. Vijesh, A. M. Isloor, S. Telkar, T. Arulmoli, H-K. Fun, Molecular docking studies of some new imidazole derivatives for antimicrobial properties. Arabian Journal of Chemistry, 6 (2013), 197-204. https://doi.org/10.1016/j.arabjc.2011.10.007
  10. D. Soliman, W. Eldehn, H. Ghabbour, H. Abdel-Azizh, Novel 6-Phenylnicotinohydrazide Derivatives: Design, Synthesis and Biological Evaluation as a Novel Class of Antitubercular and Antimicrobial Agents, Biol. Pharm. Bull., 40 (2017) 1883-1893.
  11. E. Yousif, A. Majeed, K. Al-Sammarrae, N. Salih, J. B. Abdullah, Metal complexes of Schiff base: Preparation, characterization and antibacterial activity. Arabian Journal of Chemistry, 10 (2017)  S1639–S1644.
  12. P. Sharma, C. LaRosa, J. Antwi, R. Govindarajan, K. A. Werbovetz. Imidazoles as Potential Anticancer Agents: An Update on Recent Studies. Molecules, 26 (2021) 4213.
  13. A. El-Mekabaty, Erlenmeyer Azlactones Synthesis, Reactions and Biological Activity. International Journal of Modern Organic Chemistry, 2 (2013) 40-66.
  14. S. Rehman, M. Ikram, Synthesis, characterization and antimicrobial studies of transition metal complexes of imidazole derivative. Bulletin of the Chemical Society of Ethiopia, 24 (2010) 201-207.
  15. E. Victor, S. Kim, S. J. Lippard, Synthesis of Bis(imidazole) Metal Complexes and Their Use in Rapid NO Detection and Quantification Devices. Inorg. Chem., 53 (2014) 12809-12821.
  16. R. Reshma, R. Joseyphus, D. Arish, R. J. Reshmi, Tridentate imidazole-based Schiff base metal complexes: molecular docking, structural and biological studies. Journal of Biomolecular Structure and Dynamics, (2021) 1-23.
  17. S. Joseyphus, C. Shiju, J. Joseph, D. Arish, Synthesis and characterization of metal complexes of Schiff base ligand derived from imidazole-2-carboxaldehyde and 4-aminoantipyrine. Spectrochim Acta A Mol Biomol Spectrosc, 133 (2014) 149-55.
  18. S. Slassi, A. Fix-Tailler, G. Larcher, A. Amine, A. El-Ghayoury, Imidazole and Azo-Based Schiff Bases Ligands as Highly Active Antifungal and Antioxidant Components. Heteroatom Chemistry, 6862170 (2019) 1-8. https://doi.org/10.1155/2019/6862170
  19. J. McGinley, M. McCann, Imidazole Schiff base ligands: Synthesis, coordination complexes and biological activities. Polyhedron, 55 (2013) 169-178.
  20. Walsh T, Quality and Reference Guidelines for Broth Microdilution Method. Journal of Clinical Microbiology, 10 (2005) 5246-5249.

International Journal of Scientific Research in Science and Technology

Downloads

Published

2019-08-30

Issue

Volume 6, Issue 4, July-August-2019

Section

Research Articles

License

Copyright (c) IJSRST

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Jalpa G. Gadara, Manhar V. Parsania "Synthesis, Characterization and Biological Activity of Metal Complexes of Novel Schiff Base Bearing Imidazole Moeity" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 6, Issue 4, pp.429-434, July-August-2019.