The Role of Uric Acid as an Antioxidant in Selected Neurodegenerative Disease Pathogenesis

Authors

  • Jagroop Singh  Ph.D (Biochemistry) Scholar, Desh Bhagat University, Mandi Gobindgarh (Punjab)India
  • Dr. Sukhraj Kaur  Professor and Head, Department of Biochemistry, Govt Medical College Amritsar Punjab, India
  • Manjinder Kaur  Nursing Officer, Government Medical college Amritsar, Punjab, India
  • Dr. Manpreet Kaur Verma  Assistant Professor, Department of chemistry, Desh Bhagat University, Gobindgarh, Punjab, India

DOI:

https://doi.org//10.32628/IJSRST229440

Keywords:

Parkinson ‘s disease, Alzheimer ‘s disease, Antioxidant.

Abstract

Uric acid, a potent antioxidant for humans, birds, reptiles, and some primate species, is the end-product of purine degradation that is formed in the xanthine/hypoxanthine reactions catalyzed by xanthine oxidase. Associated with the evolutionary loss of urate oxidase (the enzyme that oxidizes uric acid resulting in the formation of allantoin) and resulting increase in concentrations of uric acid is a prolonged life span. Uric acid is known to scavenge peroxynitrite and other free radicals that can cause an imbalance of oxidants leading to oxidative stress. Uric acid also has a role in protecting DNA from single-strand breaks caused by free radicals in the body leading to a protective effect in neurodegenerative diseases. The brain is particularly vulnerable to oxidative stress as it is considered an ‘expensive tissue’ with a particularly high metabolic rate and comparatively increased utilization of oxygen. Brain tissue is also high in unsaturated lipids, which makes it more susceptible to free radical damage. Oxidative stress is thus linked to the pathogenesis of neurodegenerative diseases and also ischemic brain injury. In this review, we summarize the function of uric acid in alleviating oxidative damage and providing protection to neural cells during injury and disease.

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International Journal of Scientific Research in Science and Technology

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Published

2022-08-30

Issue

Volume 9, Issue 4, July-August-2022

Section

Research Articles

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How to Cite

[1]
Jagroop Singh, Dr. Sukhraj Kaur, Manjinder Kaur, Dr. Manpreet Kaur Verma, " The Role of Uric Acid as an Antioxidant in Selected Neurodegenerative Disease Pathogenesis, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 9, Issue 4, pp.239-247, July-August-2022. Available at doi : https://doi.org/10.32628/IJSRST229440