Biological Screening of Polypyridyl Chloro–Ruthenium(II) Complexes : Antimicrobial and DNA Interaction

Authors

  • Dr. Deepen S. Gandhi  Government Science College, Sector-15, Gandhinagar, Gujarat, India

Keywords:

polypyridine; Ru(II) complex; DNA interaction; Antibacterial

Abstract

Polypyridyl ruthenium(II) complexes were synthesized and characterized. Binding mode of the complexes to DNA was evaluated from combine results of electronic absorption and viscosity measurement study. The results suggest that complexes 1, 2 and 3 bind to DNA via classical intercalation, electrostatic interaction and partial intercalation, respectively. Complex 2 shows less affinity for DNA. Cleavage of pUC19 DNA by complexes was checked using gel electrophoresis. The data reveals that highest cleaving ability is of complex 1.

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International Journal of Scientific Research in Science and Technology

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Published

2019-08-30

Issue

Volume 6, Issue 4, July-August-2019

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Research Articles

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How to Cite

[1]
Dr. Deepen S. Gandhi "Biological Screening of Polypyridyl Chloro–Ruthenium(II) Complexes : Antimicrobial and DNA Interaction" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 6, Issue 4, pp.457-468, July-August-2019.