Synthesis and Antimicrobial Evaluation of Novel Hexahydroquinolines
Keywords:
Polyhydroquinolines, Hexahydroquinolines, Multi-component reaction; Antibacterial activity; Antifungal activity.Abstract
A series of diversely substituted hexahydroquinolines have been synthesized using a one pot multi-component approach. All the newly synthesized hexahydroquinolines were characterized by different spectroscopic techniques and elemental analyses. All the compounds were evaluated for their antibacterial and antifungal activity against selected bacterial and fungal strains.
References
- Mansour, S., Mostafa, M., Mohammed, S. and Mostafa, M., Synthesis and in vitro anticancer evaluation of some novel hexahydroquinoline derivatives having a benzenesulfonamide moiety. (2011). European Journal of Medicinal Chemistry, 46: 201-207.
- Rahime, Ş., Burçin, İ. And İnci, S. (2000). Synthesis and calcium antagonistic activity of 2,6,6-trimethyl-3-carbomethoxy(ethoxy)-4-aryl-1,4,5,6,7,8-hexahydroquinoline derivatives. Il Farmaco, 55: 665-668.
- Safak, C., Erdemli, I. and Sunal, R. (2003). Synthesis of some 1,4,5,6,7,8-hexahydroquinoline derivatives and their calcium antagonistic activity. Arzneimittelforschung, 43: 1052–1055.
- Şimşek, R., Şafak, C., Erol, K. and Sirmagül, B. (2001). Studies on calcium antagonist activities of 2-ethyl-3-carbmethoxy-4-aryl-5-oxo-6,6-dimethyl-1,4,5,6,7,8-hexahydroquinoline derivatives. Arzneimittelforschung, 51: 959–963.
- Kısmetli, E., Şafak, C., Erol. K., Sırmagül, B. and Linden, A. (2004). Studies on 3-diethyl-aminocarbonyl-1,4,5,6,7,8-hexahydroquinoline derivatives and their calcium channel antagonistic activities in vitro. Arzneimittelforschung, 54: 371–375.
- Zarghi, A., Sabakhi, I., Topuzyan, V., Hajimahdi, Z. and Daraie, B. (2014). Design, synthesis and biological evaluation of 5-oxo-1,4,5,6,7,8 hexahydroquinoline derivatives as selective cyclooxygenase-2 inhibitors. Iran J Pharm Res, 13: 61-65.
- Miri, R., Javidnia, K., Mirkhani, H., Hemmateenejad, B. and Sepeher Z. (2007). Synthesis, QSAR and calcium channel modulator activity of new hexahydroquinoline derivatives containing nitroimidazole. Chem. Biol. Drug Des., 70: 329-336.
- Yang, X.-H., Zhang, P.-H., Zhou, Y., Liu, C., Lin, X. (2011). Synthesis and antioxidant evaluation of novel 4-aryl-hexahydroquinolines from lignin. Arkivoc, 10: 327–337.
- El-Khouly, A., Gündüz, M., Cengelli, C., Şimşek, R. and Erol, K. (2013). Microwave-assisted synthesis and spasmolytic activity of 4-indolylhexahydroquinoline derivatives. Drug Res, 63: 579-585.
- Faidallah, H., Rostom, S. (2013). 3-Cyano-8-methyl-2-oxo-1,4-disubstituted-1,2,5,6,7,8-hexahydroquinolines: synthesis and biological evaluation as antimicrobial and cytotoxic agents. Journal of Enzyme Inhibition and Medicinal Chemistry, 28(1):123-130.
- Gouhar, R., Fathy, U., El-Zahar, M., Kamel, M. and Awad, G. (2017). Synthesis of novel 1,4,5,6,7,8-hexahydroquinolines of potential antimicrobial activity. Acta Poloniae Pharmaceutica - Drug Research, 74: 147-159.
- Vazirimehr, S., Davoodnia, A., Tavakoli-Hoseini, N. (2017). Ultrasonic synthesis, characterization, and antibacterial evaluation of novel heterocycles containing hexahydroquinoline and pyrrole moieties. Heterocyclic Communications, 23(1): 65-70.
Downloads
Published
Issue
Section
License
Copyright (c) IJSRST

This work is licensed under a Creative Commons Attribution 4.0 International License.