Microwave Assisted One-Pot Synthesis of Amino Substituted Tetrahydroquinolines

Authors

  • Dipti Dodiya  Department of Chemistry, Government Science College, Gandhinagar, Gujarat, India

Keywords:

Tetrahydroquinolines, Multi-Component Reaction, Antibacterial Activity, Antifungal Activity.

Abstract

Microwave assisted one pot synthesis of novel amino substituted tetrahydroquinoline-3-carbonitriles has been reported by the reaction of cyclohexanone and arylidene malononitriles. The newly synthesized amino substituted tetrahydroquinoline-3-carbonitriles were characterized using different spectroscopic techniques and elemental analyses. The tetrahydroquinoline-3-carbonitriles were screened for their antibacterial and antifungal activity against different strains of bacteria and fungi respectively.

References

  1. Rahime Ş, UBurçin İ, Cihat Ş, İnci S. 2000. Il Farmaco. 55:665-668.
  2. Saleh A, Areej M, Ahmed MA, Mostafa MH, Eman N, Mostafa MG. 2009. Bioorganic Medicinal Chemistry Letters. 19:6939-6942.
  3. Santos MR, Duarte YB, Güiza FM, Bohórquez AR, Mendez-Sanchez SC. 2019. Chemico-biological interactions. 30:164-171.
  4. Lam KH, Lee KK, Gambari R, Wong RS, Cheng GY, Tong SW, Chan AS. 2013. Phytomedicine. 20:166-171.
  5. Yang XH, Zhang PH, Zhou YH, Liu CG, Lin XY. 2011. Arkivoc. 10:327–337. 
  6. Ohnishi H, Kosuzume H, Yamaguchi K, Ohkura M, Satoh M, Uohama, M, & Suzuki, Y. 2001. The Japanese Journal of Pharmacology. 31:747-756.
  7. Cetien G. 2019. Medicinal Chemistry Reports. 2:25-32.
  8. Muli P, Chobe S, Kamble R. 2014. World Journal of Pharmaceutical Research. 3:728-735.
  9. Walsh T. 2005. Journal of Clinical Microbiology. 10:5246-5249

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Published

2018-07-30

Issue

Section

Research Articles

How to Cite

[1]
Dipti Dodiya, " Microwave Assisted One-Pot Synthesis of Amino Substituted Tetrahydroquinolines , International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 4, Issue 9, pp.464-466, July-August-2018.