NANOSPONGES : A New Approach for Drug Delivery System

Authors

  • G. J. Dhumal  Ashokrao Mane Institute of Pharmaceutical Sciences & Research Save, Tal- Shahuwadi, Dist- Kolhapur, Maharashtra, India
  • A. S. Kulkarni  Ashokrao Mane Institute of Pharmaceutical Sciences & Research Save, Tal- Shahuwadi, Dist- Kolhapur, Maharashtra, India
  • K. K. Bandal  Ashokrao Mane Institute of Pharmaceutical Sciences & Research Save, Tal- Shahuwadi, Dist- Kolhapur, Maharashtra, India
  • R. H. Dambe  Ashokrao Mane Institute of Pharmaceutical Sciences & Research Save, Tal- Shahuwadi, Dist- Kolhapur, Maharashtra, India
  • V. R. Thorat  Ashokrao Mane Institute of Pharmaceutical Sciences & Research Save, Tal- Shahuwadi, Dist- Kolhapur, Maharashtra, India
  • T. T. Patil  Ashokrao Mane Institute of Pharmaceutical Sciences & Research Save, Tal- Shahuwadi, Dist- Kolhapur, Maharashtra, India
  • K. K. Dhayagonde  Ashokrao Mane Institute of Pharmaceutical Sciences & Research Save, Tal- Shahuwadi, Dist- Kolhapur, Maharashtra, India

DOI:

https://doi.org//10.32628/IJSRST229617

Keywords:

Nanosponges, Bioavailability, Controlled Release, Targeted Drug Release, Poorly Water-Soluble Drugs

Abstract

An ideal drug delivery system will solubilize the drug and achieves proficient concentration of drug at the targeted site for a specific period of time in order to increase the bioavailability with minimal side effects. Topical drug delivery system challenged with many complications like poor permeability, skin irritation, allergic reactions etc. Nanosponges are one of the carriers which solve the difficulties of drug toxicity and poor bioavailability as they can entrap both lipophilic and hydrophilic drugs. Nanosponges are minute sized having diameter below 1µm with 3-dimensional network and they can easily penetrate through the skin. Nanosponges play vital role in targeting drug delivery in a controlled manner. They are highly porous in nature having ability to capsulate variety of drug moieties and offer controlled release at the targeted site. Nanosponges can be formulated as oral, parenteral, topical or inhalation dosage forms. Controlled release of the capsulated active agent at the targeted site and solubility improvement of poorly water-soluble drugs are key advantages of Nanosponges drug delivery systems. The present review discusses about Nanosponges, method of preparations, characterisation and applications particularly in the targeted drug delivery system.

References

  1. Shringirishi M, Prajapati SK, Alok M, Yadav P, Verma A. Nanosponges: a potential nanocarrier for novel drug delivery-a review. Asian Pacific Journal of Tropical Disease 2014; 4:519-526.
  2. Shastrulagari S, Kranthy KP. Nanosponges - Novel emerging drug delivery system: a review. International journal of pharmaceutical sciences and research 2015; 6(2):529-540.
  3.  Bachkar BA, Gadhe LT, Mahajan N, Battase P, Wagh R. Nanosponges: a potential nanocarrier for targeted drug delivery. World Journal of Pharmaceutical Research 2014; 4(3); 751-768.
  4. Gursalkar T, Bajaj A, Jain D. Cyclodextrin based nanosponges for pharmaceutical use: A review. Acta Pharm. 2013; 63: 335–358.
  5. Tamkhane V, Sharma PH. Nanosponge - A Novel Drug Delivery System. Journal of Current Pharma Research 2014: 4(3):1186-1193.
  6. Ramnik S, Nitin B, Jyotsana M, Horemat SN. Characterization of Cyclodextrin Inclusion complexes –A Review. Journal of Pharmaceutical Sciences and Technology 2010; 2(3):171-183.
  7. Subramanian S, Singireddy A, Krishnamoorthy K, Rajappan M. Nanosponges: a novel class of drug delivery system-review. Journal of Pharmacy and Pharmaceutical Sciences, 2012; 15(1): 103-111.
  8. Nilesh J, Ruchi J, Navneet T, Brham PG, Deepak Kumar J. Nanotechnology : A Safe and Effective Drug Delivery Systems. Asian Journal of Pharmaceutical and Clinical Research, 2010; 3(3): 159-165.
  9. Ramnik S, Nitin B, Jyotsana M, Horemat S N. Characterization of Cyclodextrin Inclusion Complexes – A Review. Journal of Pharmaceutical Sciences and Technology 2010; 2(3): 171-183.
  10. Rajeswari C, Alka A, Javed A, Khar RK. Cyclodextrins in drug delivery: an update review. AAPS pharm Sci Tech, 2005; 6(2): E329-E357.
  11. Khalid AA, Pradeep RV, Francesco T, Roberta C. Cyclodextrin-based nanosponges for delivery of Resveratrol: In Vitro characterisation, stability, cytotoxicity and permeation Study. AAPS PharmSciTech, 2011; 12(1): 279-286.
  12. Patel EK, Oswal RJ. Nanosponge and Microsponges: A Novel Drug Delivery System. IJRPC 2012; 2(2): 237-244.
  13. Patel SB, Patel HJ and Seth AK. Nanosponge Drug Delivery System: An Overview. Journal of Global Pharma Tech 2010; 2(8):1-9.
  14. Bolmal UB, Manvi FV, Kotha R, Palla SS, Paladugu A. Recent advances in nanosponges as drug delivery system. International journal of pharmaceutical sciences and nanotechnology 2013; 6(1):1934-1944.
  15. Lala R, Thorat A, Gargote C. Current trends in β-cyclodextrin based drug delivery systems. International journal of research in Ayurveda and pharmacy 2011; 2(5):1520-1526.
  16. Tejashri G., Amrita B., Darshana J., Cyclodextrin based nanosponges for pharmaceutical use: A review. Acta Pharmaceutica, 2013; 63(3): 335-358.
  17. Moya-Ortega M.D., Alvarez-Lorenzo C. Concheiro A., Loftsson T., Cyclodextrin-based nanogels for pharmaceutical and biomedical applications. International Journal of Pharmaceutics, 2012; 428: 152-163.
  18. Cavalli R., Trotta F., Tumiatti W., Cyclodextrinbased Nanosponges for Drug Delivery. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2006; 56: 209-213.
  19. Thakre AR, Gholse YN, Kasliwal RH. Nanosponges: A novel approach of drug delivery system. Journal of medical pharmaceutical and allied sciences 2016; 78-92.
  20. Jilsha G, Viswanad V. Nanosponges: A novel approach of drug delivery system. International journal of pharmaceutical sciences review and research2013; 19(2):119-123.
  21. Ramnik S, Nitin B, Jyotsana M, Horemat S N. Characterization of Cyclodextrin Inclusion Complexes – A Review. Journal of Pharmaceutical Sciences and Technology, 2010; 2(3):171-183.
  22. Jenning V, Schafer-Korting M, Gohla S. Vitamin A loaded solid lipid nanoparticles for topical use: drug release properties. Journal of controlled release, 1999; 66: 115-126.
  23. Orlu M, Cevher E, Araman A., Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. International Journal of Pharmaceutics, 2006; 318:103-117.
  24. Shankar G, Agrawal YK. Formulation and evaluation of β-cyclodextrin based nanosponges of a poorly water soluble drug. Journal of chemical and pharmaceutical research 2015; 7(4):595-604.
  25. Tiwari H, Mahor A, Dixit ND, Kushwaha M. A review on nanosponges. World journal of pharmacy and pharmaceutical sciences 2014; 3(11): 219-233.
  26. Mahajan AG., Jagtap LS. Chaudhari AL., Swami SP. Formulation and Evaluation of Microsponge Drug Delivery System using Indomethacin. International Research Journal of Pharmacy, 2011; 2(10): 64-69.
  27. Cavalli R, Ansari K.A, Vavia P.R. Nanosponges formulations as oxygen delivery systems. International journal of pharmaceutics 2010; 402: 247-254.
  28. Sharma R., Roderick B., and Pathak K., Evaluation of kinetics and mechanism of drug release from Econazole nitrate Nanosponges loaded carbopol Hydrogel. Indian J of Pharma Edu and research, 2011; 45(1): 25-31.
  29. Ansari K. A, Torne S. J, Vavia P. R, Trotta F, Cavalli R. Paclitaxel loaded nanosponges: in-vitro characterization and cytotoxicity study on MCF-7 cell line culture. Current Drug Delivery. 8(2): 2011; 194-202.
  30. Vyas S.P., Khar R.K. Targeted and Controlled Drug Delivery- Novel Carrier Systems. Molecular Basis of Targeted Drug Delivery. CBS Publishers and Distributors. New Delhi. 2008: 38- 40.
  31. D’souza J. I. The Microsponge Drug Delivery System: For Delivering and Active Ingredient by Controlled Time Release. Pharma info.net 2008; 6(3): 62.

International Journal of Scientific Research in Science and Technology

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Published

2022-12-30

Issue

Volume 9, Issue 6, November-December-2022

Section

Research Articles

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How to Cite

[1]
G. J. Dhumal, A. S. Kulkarni, K. K. Bandal, R. H. Dambe, V. R. Thorat, T. T. Patil, K. K. Dhayagonde, " NANOSPONGES : A New Approach for Drug Delivery System, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 9, Issue 6, pp.170-178, November-December-2022. Available at doi : https://doi.org/10.32628/IJSRST229617