Identification and screening of Aegel marmelos compounds against viral infection

Authors

  • Umme Aiman Md. S Kumthe  Department of PG Studies and Research in Bioinformatics, , Solapur, Maharashtra, India
  • Vinod P Sinoorkar  Walchand Center for Biotechnology, Solapur, Maharashtra, India

DOI:

https://doi.org//10.32628/IJSRST229628

Keywords:

Aegel Marmelos, Viral Infection, Bael Tree, Phyto-Compounds

Abstract

Advanced medicines and pills have become such an important part of people`s lives that Ayurveda seems to have vanished from the picture completely. But Ayurveda contains some medicinal plants and herbs which can effectively treat and cure multiple health problems and can be great for your overall health. These Plants have been a part of our lives since our existence and have been used for various medicinal purposes since ancient times. Medicinal plants and herbs like Basil leaves, Bael Tree, Aloe Vera, Tulsi, etc. One of the best and well know medicinal plant is Bael Tree 'A.marmelos'. Various phytoconstituents like alkaloids, coumarins and steroids have been isolated and identified from different parts of the Bael tree such as leaves, fruits, wood, root and bark. It will help to cure the viral infections like Dengue, HIV, and Hepatitis etc. Hence the present study carried out to uncover the basic molecular properties of potent bioactive compounds of A.marmelos and analyse their drug likeliness and ADMET properties using bioinformatics tools and databases.

References

  1. Monath, T. P. and Heinz, F.X. (1996) 2005 Flaviviruses. In fields of Virology. (Eds) 3rd edition pp 961-1034. Lippincott-Raven, Philadelphia. Indian Journal of Clinical Biochemistry.
  2. Javanmardia J, Stushnoff C, Lockeb E, Vivancob JM.2003Antioxidant activity and total phenolic content of Iranian Ocimum accessions: Food Chem.
  3. Noble CG, Chen YL, Dong H, Gu F, Lim SP, Schul W, et al. 2010 Strategies for development of dengue virus inhibitors. Antiviral Res.
  4. Lucas Cunha Dias de Rezende, .1999 Victor Hugo Aquino and Flavio da Silva Emery. DENGUE FEVER Recent Advances in the Discovery of Small Organic Molecules for the Prevention and Treatment of Dengue Fever.
  5. Kielian, M.C. and Helenius. (1986) 2005 A "Role of cholesterol in fusion of Semliki Forest virus with membranes" J. Virol. pp. R565-R569. Indian Journal of Clinical Biochemistry.
  6. Ramakrishnan SP, Geljand HM, Bose PN et al. The epidemic of acute haemorrhagic fever, Calcutta, 1963; epidemiological inquiry. Indian J Med Res 1964; 52: 633–650.
  7. Seema and S.K.Jain. Indian Journal of Clinical Biochemistry, 2005, 20 (2) 92-103.
  8. Niyomrattanakit P, Chen YL, Dong H, Yin Z, Qing M, et al. (2010) Inhibition of dengue virus polymerase by blocking of the RNA tunnel. J Virol 84: 5678-5686.
  9. Frias-StaheliN, Dorner M, Marukian S, Billerbeck E, Labitt RN, et al. (2014) Utility of humanized BLT mice for analysis of dengue virus infection and antiviral drug testing. J Virol 88: 2205-2218.
  10. WHO Traditional medicine: Growing needs and potential, WHO policy perspectives on medicines.p.1, World Health Organization, Geneva. 2002.
  11. Prusti A, Mishra SR, Sahoo S and Mishra SK. Antibacterial activity of some Medicinal plants Ethan botanical Leaflets. 2008; 2: 227-30
  12. Jain SK and Sastry ARK. Threatened Plants in India. Botanical Survey of India. Calcutta. WB, India 1979.
  13. Author links open overlay panelManjeshwar ShrinathBaliga  Harshith P.Bhat  NandhiniJoseph  FarhanFazal  Food Research International, August 2011.

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Published

2022-12-30

Issue

Section

Research Articles

How to Cite

[1]
Umme Aiman Md. S Kumthe, Vinod P Sinoorkar, " Identification and screening of Aegel marmelos compounds against viral infection, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 9, Issue 6, pp.219-227, November-December-2022. Available at doi : https://doi.org/10.32628/IJSRST229628