Evaluation of Heterogeneity and Conformity Index Using IMRT and VMAT Techniques in Breast Cancer

Authors

  • Nuriani Nainggolan  Department of Physics, Faculty of Sciences and Mathematics, Diponegoro University, Semarang - Indonesia
  • Heri Sutanto  Department of Physics, Faculty of Sciences and Mathematics, Diponegoro University, Semarang - Indonesia
  • Eko Hidayanto  Department of Physics, Faculty of Sciences and Mathematics, Diponegoro University, Semarang - Indonesia

DOI:

https://doi.org/10.32628/IJSRST2310150

Keywords:

Radiotherapy, Breast Cancer, Treatment Planning System, Dose Distribution

Abstract

One of the most prevalent cancers in both men and women is breast cancer. A number of choice therapy covers surgery, radiotherapy, chemotherapy, and hormonal therapy. Radiotherapy is typically used as a cancer treatment because it can eliminate cancer cells and aid in preventing cancer recurrence following surgery. Dose planning must be completed before irradiating the patient. Planning is carried out in a treatment planning system (TPS) with several available technique options. In this study, we chose intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) techniques. To determine the quality of the dose planning of these two techniques, a comparison of the heterogeneity index (HI) and conformity index (CI) parameters was carried out. The results of the comparison between IMRT and VMAT show that VMAT is superior to IMRT in terms of homogeneity and conformity. This is consistent with the HI results on VMAT showing a mean of 1.060 while IMRT shows a mean of 1.081. In addition, the CI results at VMAT showed a mean of 0.641 while IMRT showed a CI value of 0.519.

References

  1. Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249.
  2. Alimirzaie, S., Bagherzadeh, M., & Akbari, M. R. (2019). Liquid biopsy in breast cancer: A comprehensive review. Clinical Genetics, 95(6), 643–660. https://doi.org/https://doi.org/10.1111/cge.13514.
  3. Bleyer, A., & Welch, H. G. (2012). Effect of Three Decades of Screening Mammography on Breast-Cancer Incidence. New England Journal of Medicine, 367(21), 1998–2005. https://doi.org/10.1056/NEJMoa1206809
  4. Waks, A. G., & Winer, E. P. (2019). Breast Cancer Treatment: A Review. In JAMA - Journal of the American Medical Association (Vol. 321, Issue 3, pp. 288–300). American Medical Association. https://doi.org/10.1001/jama.2018.19323
  5. Clarke, M. (2005). Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet, 365, 1687–1717.
  6. Akino, Y., Das, I. J., Bartlett, G. K., Zhang, H., Thompson, E., & Zook, J. E. (2013). Evaluation of superficial dosimetry between treatment planning system and measurement for several breast cancer treatment techniques. Medical Physics, 40(1). https://doi.org/10.1118/1.4770285
  7. Wei, Z., Peng, X., Wang, Y., Yang, L., He, L., Liu, Z., Wang, J., Mu, X., Li, R., & Xiao, J. (2021). Influence of target dose heterogeneity on dose sparing of normal tissue in peripheral lung tumor stereotactic body radiation therapy. Radiation Oncology, 16(1). https://doi.org/10.1186/s13014-021-01891-6
  8. Tas, B., Durmus, I. F., Uzel, O. E., & Okumus, A. (2017). Conformity Index, Gradient Index, Heterogeneity Index, and Size of Metastasis Correlations for LINAC-Based Stereotactic Radiosurgery/Radiation Therapy. International Journal of Radiation Oncology, Biology, Physics, 99(2), E727. https://doi.org/10.1016/j.ijrobp.2017.06.2351
  9. Haciislamoglu, E., Colak, F., Canyilmaz, E., Dirican, B., Gurdalli, S., Yilmaz, A. H., Yoney, A., & Bahat, Z. (2015). Dosimetric comparison of left-sided whole-breast irradiation with 3DCRT, forward-planned IMRT, inverse-planned IMRT, helical tomotherapy, and volumetric arc therapy. Physica Medica, 31(4), 360–367. https://doi.org/https://doi.org/10.1016/j.ejmp.2015.02.005
  10. N, Hodapp. (2012). The ICRU Report 83: prescribing, recording and reporting photon-beam intensity-modulated radiation therapy (IMRT).

International Journal of Scientific Research in Science and Technology

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Published

2023-02-28

Issue

Volume 10, Issue 1, January-February-2023

Section

Research Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Nuriani Nainggolan, Heri Sutanto, Eko Hidayanto "Evaluation of Heterogeneity and Conformity Index Using IMRT and VMAT Techniques in Breast Cancer " International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 10, Issue 1, pp.370-373, January-February-2023. Available at doi : https://doi.org/10.32628/IJSRST2310150