Solubility and Dissolution Enhancement of Budesonide by Solid Dispersion Using Rotary Evaporation Method

Authors

  • Ankita Zunjkar  Department of Quality Assurance, D.S.T.S Mandal’s College of Pharmacy, Solapur, Maharashtra, India
  • Prof. Afaque Raza Mehboob Ansari  Department of Quality Assurance, D.S.T.S Mandal’s College of Pharmacy, Solapur, Maharashtra, India

DOI:

https://doi.org/10.32628/IJSRST523103212

Keywords:

Budesonide, PVP K-35, HPMC K-15

Abstract

The aim of the present study was to formulate and evaluate budesonide solid dispersion using PVP K-35 and HPMC K-15 polymers with the help of solvent evaporation method followed by rotary evaporation method to improve solubility and dissolution of budesonide. Solid dispersion of budesonide was prepared with different drug: carrier ratios using solvent evaporation method followed by rotary evaporation method. F1 to F9 batches were prepared. The solubility study of F1 to F9 batches were carried out. Batch F6 has shown highest solubility, and was F6 batch was selected as optimized batch. FT-IR and DSC were performed to identify the physicochemical interactions between drug and optimized formulation. The dissolution test was carried out to check the percentage drug release of solid dispersion. The drug release of solid dispersion is after 60 min was 9.92% for optimized batch.

References

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International Journal of Scientific Research in Science and Technology

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Published

2023-06-30

Issue

Volume 10, Issue 3, May-June-2023

Section

Research Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Ankita Zunjkar, Prof. Afaque Raza Mehboob Ansari "Solubility and Dissolution Enhancement of Budesonide by Solid Dispersion Using Rotary Evaporation Method" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 10, Issue 3, pp.44-49, May-June-2023. Available at doi : https://doi.org/10.32628/IJSRST523103212