Synthesis and in Vitro Cytotoxicity Evaluation of Isatin-Pyrrole Derivatives against HepG2 Cell Line
Keywords:
isatin; isatin-pyrrole derivatives; anticancer; HepG2 cell line.Abstract
This paper reports the synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives 5–8, obtained from the appropriate isatins with pyrrole, with good yields and purity. The product structures were confirmed through spectroscopy methods. Furthermore, the MTT assay on the human liver cancer HepG2 cell lines revealed moderate activity in all compounds, which was highest in sample 6 (IC50 0.47 µM). The anticancer activity was affiliated with the presence of a nitro group at C-5 and N-methyl of the isatin scaffold.
References
- Sridhar SK, Pandeya SN, Stables JP, Ramesh A(2002)Anticonvulsant activity Of hydrazones, Schiff and Mannich bases of isatin derivatives. European Journal of Pharmaceutical Science 16(3): 129-132
- Verma M, Pandeya SN, Singh KN, Stables(2004)JP. Acta 54: 36-49
- Pandeya SN , S D Natgh G,de Clereq E(2000) Synthesis of antifungal and anti HIV evaluation of Schiff and Mannich bases of isatin and its derivatives with trizole. Arzneimittel Forsch 50(1): 55-59
- K. Gangarapu, S. Manda, A. Jallapally et al., "Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents," Medicinal Chemistry Research, vol. 23, no. 2, pp. 1046-1056, 2014
- Mamedova YV, Hasanova AE, Gasimova Sz, Huseynova RA, Mamedov IG. Some isatin based Synthesis. New materials, Compoundds and Application, 2020; 4(1) : 16-9.
- Prudhomme M. Advances in Anticancer Agents in Medicinal Chemistry. [Internet]. Sharjah: Bentham Science Publishers; 2013 [cited 2021 Sep 24].
- Singh R, Sharma S, Banarasi B. Synthesis, Characterization And Evaluation of 2-Imino Benzothiazole Derivatives As Anticonvulsant Agents. International Journal of Pharmaceutical Sciences and Research. 2021; 5(5):213-217.
Downloads
Published
2022-03-30
Issue
Section
Research Articles
License
Copyright (c) IJSRST
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
[1]
Mukesh, Dr Anushree Gupta "Synthesis and in Vitro Cytotoxicity Evaluation of Isatin-Pyrrole Derivatives against HepG2 Cell Line" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 9, Issue 2, pp.590-596, March-April-2022.