Exploration of 5 -ASA
Keywords:
5 – Amino Salicylic Acid, Physical DataAbstract
5-amino- 2-hydroxyl benzoic acid (5-ASA) is also known as Mesalamine is very important molecule for human being. This molecule has several important bio chemical functions to play. This molecule has amino (-NH2 group), Carboxylic (-COOH group) and phenolic hydroxyl (-OH group). Elemental data, IR – spectra, Proton and 13C NMR spectra of 5 -ASA are here. This molecule has water solubility and capability to perform biochemical functions. Further Amino, Carboxylic and phenolic hydroxyl unit has tremendous ability to form Metal Chelates with 3d ,4d and 5d metal ions that are biologically active.
References
- Preparation by reduction of m-nitrobenzoic acid with Zn dust and HCl: H. Weil et al. Ber.55B, 2664 (1922); by electrolytic reduction. Le Guyader, Peltier. Compt. Rend 253, 2544 (1961).
- Use in manufacture of dyes: GB751386 (1956 to J. R. Geigy). Identification as active metabolite of sulfasalazine, q.v. A. Κ. Azad Khan et al., Lancet2, 892 (1977),
- P.A. M. Van Heeset al., Guf21, 632 (1980), HPLC determine in serum.
- Brendel et. al. J. Chromatogram 385, 299 (1987). Bioavailability, plasma level and excretion: S. N. Rasmussen et al., Gastroenterology83, 1062 (1982).
- Clinical evaluation in Crohn's disease: eider, ibid.85, 1350 (1983). Clinical trials in ulcerative colitis: M. Campimetries al, Lancer2, 270 (1981);
- L. S. Friedman et al. Am. J. Gastroenterol 81, 412 (1986), in comparison with olsalazine, q.v. S. S. Ravet al., Scand J Gastroenterol. 22, 332 (1987).
- Brief review: G. Friedman, Am. J. Gastroenterology 81, 141-144 (1986).
- Review of clinical efficacy in colonic diverticulosis: A. Tursi, Expert Opine. Pharmacotherapy 6, 69-74 (2005).
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