Polyhydroquinoline : Different Methods of Synthesis and its Various Biological Activities

Authors

  • Santosh V. Padghan   Department of Chemistry, Sant Dnyaneshwar Mahavidyalaya, Soegaon, Dist-Aurangabad, Maharashtra, India

DOI:

https://doi.org/10.32628/IJSRST52310474

Keywords:

Substituted polyhydroquinoline derivatives, anticancer, antitubercular, neurotrophic agent

Abstract

Substituted polyhydroquinoline derivatives are an important class of heterocyclic compounds. In recent years, heterocyclic analogues and its derivatives have attracted strong interest due to their immense importance in the design and discovery of new compounds for pharmaceutical applications. Polyhydroquinoline derivatives are a class of chemical compounds that exhibit a wide range of biological and pharmacological activities such as anticancer, antitubercular, nuerotrophic and effective cardiovascular agents. The current review focuses on various approaches for synthesizing substituted polyhydroquinoline with potential activities.

References

  1. Behbahani, F. K., & Homafar, M., Synthesis and reactivity in Inorganic, Metal-Organic 2012, 42, 291-295.
  2. Buhler & Kiowski, 1987, 05, p S3-10.
  3. Eharkar, P. S., Desai, B., Gaveria, H., Varu, B., Loriya, R. ,Naliapara, Y., Shah, A., and Kulkarni, V. M., J. Med. Chem.,2002, 45, 4858–4867.
  4. Tsuruo, T., Iida, H., Nojiri, M., Tsukagoshi S., and Sakurai, Y.,Cancer Res., 1983, 43, 2905–2910.
  5. Krauze, A., Germane, S., Eberlins, O., Sturms, I., Klusaand, V., Duburs, G., Eur; J. Med. Chem., 1999, 34, 301–310.
  6. Poindexter, G. S., Bruce, M. A., Breitenbucher, J. G.,Higgins, M. A., Sit, S. Y., Romine, J. L., Martin, S. W.,Ward, S. A., McGovern, R. T., Clarke, W., Russell J., and Antal-Zimanyi, I., Bioorg,.Med. Chem., 2004, 12, 507–521.
  7. Klusa , V., Drugs Future, 1995, 20, 135–138.
  8. Bretzel, R. G., Bollen, C. C., Maeser, E., and Federlin, K. F., Am. J .Kidney Dis, 1993, 21, 53–64.
  9. Chapman, R. W., Danko G., and Siegels, M. I., Pharmacology, 1984, 29, 282–291.
  10. Ogawa, A. K.,Willoughby, C. A., Bergeron, R., Ellsworth, K. P., Geissler, W. M., Myer, R. W., Yao, J., Harris G., and Chapman, K. T., Bioorg. Med. Chem. Lett., 2003, 13, 3405–3408.
  11. Bretzel, R. G., Bollen, C. C., Maeser, E., Federlin, K. F., Drugs Fut., 1992, 17, 465.
  12. Boer, R., Gekeler, V., Drugs Fut., 1995, 20, 499.
  13. Wang, H., Tang, M., synthesis, 2017, 49(21), 4893-4898.
  14. Bagley, M. C., Fusillo, V., Jenkins, R. L., Caterina Labinu, M., Malon, M., Beilstein J. Org. Chem, 2013, 9, 1957-1968.
  15. Hashemi-Uderji, S., Abdollahi-Alibeik, M., Ranjbar-Karimi, R., Main Group Met. Chem. 2018, 41(3-4), 91-101.
  16. Xia, J. J., Zhang, K. H., Molecules, 2012, 17, 5339-5345.
  17. Sharma, M. G., Rajani, D. P., Patel, H. M., Royal Society Open Science, 2017, 4(6).
  18. Kenu, N., Maddila, S., Jonnalagadda, S. B., Front. Chem., 2021.
  19. Mojarrad, J. S., Vo, D., Velazquez, C., Knaus, E. E., Bioorganic and medicinal Chemistry, 2005, 13, 4085-4091
  20. Dharma Rao, G. B., Nagakalyan s., and Prasad, G. K., RSC Advances, 2017, 7(6), 8611-3616.
  21. Raouf, H., Allameh, S., Beiramabadi, S. A., Morsali, A., J. Biochem Tech, 2018, 9(1), 61-64.
  22. Alinezhad H., and Tavakkoli, S. M., The Scientific World Journal, 2013, 1-9.
  23. Ladani, N. K., Mungra, D. C., Patel, M. P., Patel, R. G., Chinese Chemical Letters, 2011, 22, 1407-1410.
  24. Jamale, D. K., Undare, S. S., Valekar, N. J., Sarkate, A. P., Kolekar, G. B., Anbhule, P. V., Journal of Heterocyclic Chemistry, 2018, vol.000.
  25. Olejnikova, P., Svorc, L., Olsovska, D., Panakova, A., Vihnoska, Z., Kovaryova, K., Marchalin, S., Scientia Pharmaceutica, 2014, 82(2), 221-232.
  26. Jadhvar, S. C., Kasralikar, H. M., Goswami, S. V., Chakravar, A. V., Bhusare, S. R., Res. Chem. Intermed, 2017, 43, 7211-7221.
  27. Fan, X.-X., Shen, P., Zhou, X.-H., Russian Journal of General Chemistry, 2018, 88, 6, 1247-1251.
  28. Karad, S. C., Purohit, V. B., Raval, D. K., Kalaria, P. N., Avalani, J. R., Thakor, P., Thakkar, V. R., RSC Advances, 2015, 5(21), 16000-16009.
  29. Kalaria, P. N., Satasia, S. P., Raval, D. K., European Journal of Medicinal Chemistry, 2014, 78, 207-216.

International Journal of Scientific Research in Science and Technology

Downloads

Published

2023-08-30

Issue

Volume 10, Issue 4, July-August-2023

Section

Research Articles

License

Copyright (c) IJSRST

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Santosh V. Padghan "Polyhydroquinoline : Different Methods of Synthesis and its Various Biological Activities" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 10, Issue 4, pp.588-596, July-August-2023. Available at doi : https://doi.org/10.32628/IJSRST52310474