Formulation And Evaluation of Diclofenac Sodium Gel By Using Carbopol 934

Authors

  • Bhakti Todmal  Shankarrao Ursal College of Pharmaceutical Science & Research Center Kharadi, Maharashtra., India
  • Anjali Pande  M. Pharm (Pharmaceutical Science) Assistant professor of Shankarrao Ursal College of Pharmaceutical Science & Research Center, Kharadi, Maharashtra, India³
  • Rachna Vidhate  
  • Gaurav Jedhe  
  • Omkar Zalte  

DOI:

https://doi.org//10.32628/IJSRST523105105

Keywords:

Topical Drug Delivery, Anti-inflammatory, Water Soluble Polymer, Carbopol934

Abstract

The present research has been undertaken with the aim to develop a topical gel of diclofenac sodium gel (DS) 1%, evaluation of its physico chemical characteristics. The main objective of this research paper is to prepare and evaluate 1% polymer containing transdermal gel of Diclofenac Sodium. The gel was prepared and evaluated for pH, Spreadability, Consistancy, Homogeneity, Drug Content, Skin Irritation test and In vitro Diffusion Study. The carbopol is high molecular weight water soluble homo polymer ehich posses high viscoty in low concentrations, transparency, and film Forming properties these are useful for gel formation. The percentage of drug release was 97.68%. In vitro drug release was evaluated by using Inhibition of protein denaturation. The diclofenac sodium was subjected to in vitro inhibition of protein denaturation in various concentrations i.e. 100, 200, 400, 800, 1000 µg/ml. The present study suggests that the Diclofenac sodium effectively act as in vitro anti-inflammatory activity.

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International Journal of Scientific Research in Science and Technology

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Published

2023-11-04

Issue

Volume 10, Issue 6, November-December-2023

Section

Research Articles

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How to Cite

[1]
Bhakti Todmal, Anjali Pande, Rachna Vidhate, Gaurav Jedhe, Omkar Zalte, " Formulation And Evaluation of Diclofenac Sodium Gel By Using Carbopol 934, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 10, Issue 6, pp.10-15, November-December-2023. Available at doi : https://doi.org/10.32628/IJSRST523105105