Recent Developments in the Synthetic Chemistry of Pyrimido [4, 5-d] pyrimidine Derivatives: A Systematic Review

Authors

  • Rameshwar R. Magar  Department of Chemistry, Sant Dnyaneshwar Mahavidyalaya, Soegaon, Dist. Aurangabad, Maharashtra, India
  • Sunil S. Choudhare  Department of Chemistry, Sant Dnyaneshwar Mahavidyalaya, Soegaon, Dist. Aurangabad, Maharashtra, India
  • Vinod K. Barote  Department of Physics, Sant Dnyaneshwar Mahavidyalaya, Soegaon, Dist. Aurangabad, Maharashtra, India

Keywords:

Pyrimido [4, 5-d] pyrimidine, Heterocyclic compound, Pharmacological activities, Synthesis.

Abstract

This review focuses on the recent development of synthesis of pyrimido [4, 5-d] pyrimidine derivatives. Pyrimido [4, 5-d] pyrimidine derivatives are important heterocyclic compound which possess diverse pharmacological activities such as anticancer, antitumor, antioxidant, antiviral, antibacterial anti-allergic and anti-inflammatory activities. Therefore, organic chemists are interested in the synthesis of these bioactive heterocycles. In this review, we have compile the recent literature report of various synthetic procedures for synthesis of pyrimido [4, 5-d] pyrimidine derivatives.

References

  1. S. M. El-Moghazy, D. A. Ibrahim, N. M. Abdelgawad, N. A. H. Farag, A. S. EL-Khouly, Sci. Pharm., 2011, 79, 429.
  2. E. M. Grivsky, S. Lee, C. W. Sigel, D. S. Duch, C. A. Nichol, J. Med. Chem. 1980, 23, 327.
  3.  J.P. De la Cruz, T. Carrasco, G. Ortega, F. Sanchez De la Cuesta, Lipids, 1992, 27, 192.
  4. H. El-Subbagh, S. M. Abu-Zaid, M. A. Mahran, F. A. Badria, and A. M. Al-Obaid, J. Med. Chem., 2000, 43, 2915.
  5. S. R. Kanth, G. V. Reddy, K. H. Kishore, P. S. Rao, B. Narsaiah, U. S. N. Murthy, Eur. J. Med. Chem., 2006, 41, 1011.
  6. N. Kitamura,A. Onishi, EU Patent 163599; Chem. Abstr. 1984, 104, 186439.
  7. E. P. Falcao, S. J. Melo, R. M. Srivastava, M. T. J. A. Catanho, S. C. Nascimento, Eur. J. Med. Chem., 2006, 41, 276.
  8. L. R. Bennet, C. J. Blankley, R. W. Fleming, R. D. Smith, D. K. Tessman, J. Med. Chem., 1981, 24, 382.
  9. V.J. Ram, A. Goel, S. Sarkhel, P.R. Maulik, Bioorg. Med. Chem. 2002, 10, 1275.
  10. G.W. Rewcastle, A.J. Bridges, D.W. Fry, J.R. Rubin, W.A. Denny, J. Med. Chem. 1997, 40, 1820.
  11. D.W. Fry, M.A. Becker, R.L. Switzer, Mol. Pharmacol. 1995, 47, 810.
  12. J. E. Gready, C. McKinlay, M. G. Gebauer, Eur. J. Med. Chem. 2003, 38, 719.
  13. A. H. Kategaonkar, S. A. Sadaphal, K. F. Shelke, B. B. Shingate, M. S. Shingare, Ukrainica Bioorgnica Acta, 2009, 1, 3.
  14. A. Bazgir, S. C. Azimi, Iran. J. Catal., 2013, 3, 21.
  15. S. Majumder, P. Borah, P. J. Bhuyan, Tetrahedron Lett. 2014, 55, 1168.
  16. Z. D. Fang, D. Fang Y. Y. Tan, Res. Chem. Intermed., 2015, 41, 1203.
  17. A. Mobinikhaledi, T. Mosleh, N. Foroughifar, Res. Chem. Intermed.2015, 41, 2985.
  18. S. Badvel, R. R. Gopireddy, T. B. Shaikh, S. Hasti, V. R. Tummaluru, N. R. Chamarthi, Chem. Heterocycl Compd, 2015, 51, 749.
  19. G. M. Bondle, S. T. Atkore J. Chem. Pharm. Res. 2016, 8, 717.
  20. P. T. Patil, P. P. Warekar, K. T. Patil, D. K. Jamale, G. B. Kolekar, P. V. Anbhule, Res. Chem. Intermed., 2017, 43, 4103.
  21. R. Ghorbni-Vaghei, N. Sarmast, Appl. Organomet. Chem. 2018, 32, 1.
  22. R. Bakhshali-Dehkordi, M. A. Ghasemzadeh, J. Safaei-Ghomi, J. Mol. Struct., 2020, 1206, 127688.
  23. M. H. Abdollahi-Basir, F. Shirini, H. Tajik, M. A. Ghasemzadeh, Polycycl. Aromat. Compd., 2021, 41, 1580.
  24. A. Mobinikhaledi, N. Ahadi, F. S. Hoseini, F. Sameri, Res. Chem. Intermed., 2023, 49, 3501.

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Published

2023-10-30

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Section

Research Articles

How to Cite

[1]
Rameshwar R. Magar, Sunil S. Choudhare, Vinod K. Barote "Recent Developments in the Synthetic Chemistry of Pyrimido [4, 5-d] pyrimidine Derivatives: A Systematic Review" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 10, Issue 5, pp.198-204, September-October-2023.