Phenytoin Drug using with Suppository Base for in Rectal Delivery System
Keywords:
Phenytoin, Suppository base, Rectal delivery, Lipid-Based –Vehicles.Abstract
The purpose of present research work is to expand various suppository bases in order to control disadvantage of traditional base and to analyses the release of Phenytoin from this bases. Cocoa butter, poloxamer 407, PEG2000 used as base and prepared by fusion method. Improved base is estimated for physicochemical parameters like appearance, hardness, weight variation, hydroxyl vale and this bases used in the preparation of Phenytoin suppositories. Suppositories of Phenytoin were estimated for physical parameter drug content, In vitro drug release reports. Selected suppositories bases were specify by X-ray diffraction, Infra Red spectroscopy studies. Physicochemical parameters of suppositories base show within limit. Hydroxyl value of bases observed in limits 89.76-134.64. From the result it is analyzed Polaxmer 407 and PEG2000 and hydrogenated vegetable oil show fast release. Physicochemical parameters of Phenytoin suppositories show within limit. Product contains poloxamer 407, hydrogenated vegetable oil shows 99.44% drug release at 120 min. within 71.83% dissolution efficiency. Infra Red spectroscopy shows affinity of drug with adjuvant and X-ray diffraction also differential scanning calorimetry show reduction in degree of crystallinity of Phenytoin. Also it can be analyzed poloxamer 407, hydrogenated vegetable oil combination useful for poorly water soluble drug like Phenytoin. Using fusion method this formulation was designed with combination of bases like Hydrogenated vegetable oil, cocoa butter, poloxamer 407and PEG2000. Thus finally it can be concluded that poloxamer 407, Hydrogenated vegetable oil combination is more suitable for poorly water soluble drug like Phenotine.
References
- Fumoleau P, Giovannini M, Rolland F, Votan B, Paillarse JM. Ondansetron suppository: An effective treatment for the prevention of emetic disorders induced by cisplatin-based chemotheraphy. Oral Oncol. 1997;33(5):354–8.
- Salunkhe NH, Jadhav NR, Mali KK, Dias RJ, Ghorpade VS, Yadav a. V. Mucoadhesive microsphere based suppository containing granisetron hydrochloride for management of emesis in chemotherapy. J Pharm Investig. 2014;44(4):253–63.
- Jadhav UG, Dias RJ, Mali KK, Havaldar VD. Development of in situ-gelling and mucoadhesive liquid suppository of ondansetron. Int J ChemTech Res. 2009;1(4):953–61.
- Prasanna LJ, Rao RN. Rectal drug delivery: A promising route for enhancing drug absorption. Asian J Res Pharm Sci. 2012;2(4):143–9.
- Swamy P V, Farhana L, Shirsand SB, Ali Y, Patil A. Design and Evaluation of Rectal Suppositories of Carvedilol. Int J Pharm Sci Nanotechnol. 2009;2(3):654–60.
- Havaldar VD, Yadav A V., Dias RJ, Mali KK, Ghorpade VS, Salunkhe NH. Rectal suppository as an effective alternative for oral administration. Res J Pharm Technol. 2015;8(6):759.
- Koliqi R, Polidori C, Islami H. Prevalence of Side Effects Treatment with Carbamazepine and Other Antiepileptics in Patients with Epilepsy. Mater Sociomed. 2015;27(3):167–71.
- Dias RJ, Mali KK, Ghorpade VS, Havaldar VD, Mohite VR. Formulation and Evaluation of Carbamazepine Liquisolid Compacts Using Novel Carriers. Indian J Pharm Educ Res. 2017;51(S2): S69–78.
- Lehr CM, Bouwstra JA, Schacht EH, Junginger HE. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int J Pharm. 1992;78(1-3):43–8.
- Jawahar N, Jayaprakash S, Maria GS, Nagarajan M, Moorthi D, Jubie S, et al. Design and evaluation of Sustained release suppositories if nimesulide. Indian J Pharm Sci. 2005;67(5):558– 61.
- Fleming J. Rapid method for the of hydroxyl values. J Soc Cosmet Chem. 1966; 630(17):625–30.
- Shinoda M, Akita M, Hasegawa M, Nadai M, Hasegawa T, Nabeshima T, et al. Pharmaceutical evaluation of carbamazepine suppositories in rats. Biosci Biotechnol Biochem. 1995;18(9):1289–91.
- Patel JK, Patel RP, Amin AF, Patel MM. Formulation and evaluation of mucoadhesive glipizide microspheres. AAPS PharmSciTech. 2005;6(1): E49–55.
- Swamy PV, Ali MY, Anand Kumar Y, Prasad K, Srinivaslu N. Design and evaluation of rectal drug delivery systems of non- steroidal anti-inflammatory drug. Int. Curr Pharm J. 2012;1(7):165–70.
- Schmllt M. Influence of the Hydrophilicity of Suppository Bases on Rectal Absorption of Carprofen, a Lipophilic Nonsteroidal Anti-inflammatory Drug. J Pharm Sci. 1990;79(4):359–63.
- Wakita K, Kuwabara H, Furusho N, Tatebe C, Sato K, Akiyama
- H. A Comparative Study of the Hydroxyl and Saponification Values of Polysorbate 60 in International Food Additive Specifications. Am J Anal Chem. 2014;05(03):199–204.
- Hermann TW. Recent research on bioavailability of drugs from suppositories. Int J Pharm. 1995;123(1):1–11.
- Baria AH, Patel RP, Suthar AM, Parmar RB. Formulation Development and Evaluation of Sustained Release Aceclofenac Suppository. Int J Pharm Sci Drug Res. 2009;1(2):71–3.
- Saleem M, Taher M, Sanaullah S, Najmuddin M, Ali J, Humaira S, et al. Formulation and evaluation of tramadol hydrochloride rectal suppositories. Indian J Pharm Sci. 2008;70(5):640.
- Costa P, Sousa Lobo JM. Modeling and comparison of dissolution profiles. Vol. 13, European Journal of Pharmaceutical Sciences. 2001. p. 123–33.
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