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Formulation and In-vitro Evaluation of Tramadol Hydrochloride Gel

Authors(3) :-Y. Phani Krishna, S. M. S. Madhuri, R. Madhuri

Tramadol is an opioid analgesic. The most common side effects with opioid analgesics are nausea and vomiting (particularly at the start of treatment), constipation, and dry mouth. Opioids can also cause drowsiness and confusion. Due to the adverse drug reactions associated with oral formulations opioid analgesics can be administered by topical route. Gelling agents like xanthan gum, carbopol are used in the formulation of Tramadol hydrochloride gel. In vitro permeability studies using a semipermeable membrane was carried out to find the optimized formulation
Y. Phani Krishna, S. M. S. Madhuri, R. Madhuri
Tramadol hydrochloride, Gel, Xanthan gum, carbopol, Permeabilty study
  1. V.R. Patel, M.M. Amiji, Preparation and characterization of freezedried chitosan-poly(ethylene oxide) hydrogels for site-specific antibiotic delivery in the stomach, Pharm. Res. 13 (1996) 588-593.
  2. N.A. Peppas, Physiologically responsive gels, J. Bioact. Compat. Polym. 6 (1991) 241-246.
  3. M. Amiji, R. Tailor, M.-K. Ly, J. Goreham, Gelatin-poly (ethylene oxide) semi-interpenetrating polymer network with pH-sensitive swelling and enzyme-degradable properties for oral drug delivery, Drug Dev. Ind. Pharm. 23 (1997) 575-582.
  4. A.M. Lowman, M. Morishita, M. Kajita, T. Nagai, N.A. Peppas, Oral delivery of insulin using pH-responsive complexation gels, J. Pharm. Sci. 88 (1999) 933-937.
Publication Details
  Published in : Volume 4 | Issue 5 | March-April 2018
  Date of Publication : 2018-04-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 341-345
Manuscript Number : IJSRST184566
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
Y. Phani Krishna, S. M. S. Madhuri, R. Madhuri, "Formulation and In-vitro Evaluation of Tramadol Hydrochloride Gel", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 4, Issue 5, pp.341-345, March-April-2018
URL : http://ijsrst.com/IJSRST184566