Formulation and In-vitro Evaluation of Tramadol Hydrochloride Gel

Authors(3) :-Y. Phani Krishna, S. M. S. Madhuri, R. Madhuri

Tramadol is an opioid analgesic. The most common side effects with opioid analgesics are nausea and vomiting (particularly at the start of treatment), constipation, and dry mouth. Opioids can also cause drowsiness and confusion. Due to the adverse drug reactions associated with oral formulations opioid analgesics can be administered by topical route. Gelling agents like xanthan gum, carbopol are used in the formulation of Tramadol hydrochloride gel. In vitro permeability studies using a semipermeable membrane was carried out to find the optimized formulation

Authors and Affiliations

Y. Phani Krishna
Department of Pharmaceutics, Sir C. R. Reddy College of Pharmaceutical Sciences, Eluru, Andhra Pradesh, India
S. M. S. Madhuri
Department of Pharmaceutics, Sir C. R. Reddy College of Pharmaceutical Sciences, Eluru, Andhra Pradesh, India
R. Madhuri
Department of Pharmaceutics, Sir C. R. Reddy College of Pharmaceutical Sciences, Eluru, Andhra Pradesh, India

Tramadol hydrochloride, Gel, Xanthan gum, carbopol, Permeabilty study

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Publication Details

Published in : Volume 4 | Issue 5 | March-April 2018
Date of Publication : 2018-04-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 341-345
Manuscript Number : IJSRST184566
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

Y. Phani Krishna, S. M. S. Madhuri, R. Madhuri, " Formulation and In-vitro Evaluation of Tramadol Hydrochloride Gel", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 4, Issue 5, pp.341-345, March-April-2018.
Journal URL : http://ijsrst.com/IJSRST184566

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