Formulation and In-vitro Evaluation of Tramadol Hydrochloride Gel

Authors

  • Y. Phani Krishna  Department of Pharmaceutics, Sir C. R. Reddy College of Pharmaceutical Sciences, Eluru, Andhra Pradesh, India
  • S. M. S. Madhuri  Department of Pharmaceutics, Sir C. R. Reddy College of Pharmaceutical Sciences, Eluru, Andhra Pradesh, India
  • R. Madhuri  Department of Pharmaceutics, Sir C. R. Reddy College of Pharmaceutical Sciences, Eluru, Andhra Pradesh, India

Keywords:

Tramadol hydrochloride, Gel, Xanthan gum, carbopol, Permeabilty study

Abstract

Tramadol is an opioid analgesic. The most common side effects with opioid analgesics are nausea and vomiting (particularly at the start of treatment), constipation, and dry mouth. Opioids can also cause drowsiness and confusion. Due to the adverse drug reactions associated with oral formulations opioid analgesics can be administered by topical route. Gelling agents like xanthan gum, carbopol are used in the formulation of Tramadol hydrochloride gel. In vitro permeability studies using a semipermeable membrane was carried out to find the optimized formulation

References

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International Journal of Scientific Research in Science and Technology

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Published

2018-04-30

Issue

Volume 4, Issue 5, March-April-2018

Section

Research Articles

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Copyright (c) IJSRST

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Y. Phani Krishna, S. M. S. Madhuri, R. Madhuri "Formulation and In-vitro Evaluation of Tramadol Hydrochloride Gel" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 4, Issue 5, pp.341-345, March-April-2018.