Solubility And Dissolution Enhancement of Budesonide by Solid Dispersion Using Rotary Evaporation Technique
DOI:
https://doi.org/10.32628/IJSRST24113101Keywords:
Occupational Structure, Agriculture Sector, Non-Agriculture Sector, Workers, Non Workers, KeralaAbstract
The Purpose of the work was to enhance the solubility and dissolution of Budesonide API Powder which was under BCS Class 2 system. Solid dispersion of Budesonide were prepared by using different polymers like Poly vinyl pyrrolidone (PVP K30), polyethylene glycol 6000 (PEG6000) by using Solvent Evaporation Method by using Rotary Evaporator, in the 1:1:1, 1:1:2, 1:1:3, 1:2:1, ratios of drug and carrier. The In-vitro release profile of all solid dispersions (F1 to F9) were comparatively evaluated and also studied against pure Budesonide. The evaluation test were carried out like drug content, solubility, drug release studies. The drug and polymer interaction was studied by using Fourier Transport Infra-Red and Differential Scanning Calorimetry, Powder X Ray Diffraction studies were also carried out to find out the Crystalinity of Solid Dispersion, SEM was carried out for study of surface morphology.
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Sekiguchi K, Obi N, Ueda Y. Studies on Absorption of Eutectic Mixture. II. Absorption of Fused Conglomerates of Chloramphenicol and Urea in Rabbits. Chemical & pharmaceutical bulletin. 1964; 12:134-44
Fincher.J.H. The Effect of the Particle Size of Drugs on Their Dissolution Rates and
Biological Availability. J. Pharma. Sci. 1968; 57(11): page no. 1825-1835.
Win Loung Chiou, Riegelman S. Pharmaceutical applications of solid dispersion systems. Journal of Pharmaceutical Sciences. 1971:60(9):1281-1302.
Planinsek, O; Kovacic, B and Vrecer, F (2011), “Carvedilol dissolution improvement by preparation of solid dispersions with porous silica”, Int J Pharm, 406, 41-48.
Choudhary, A; Rana, AC; Aggarawal, G, Kumar, V and Zakir, F (2012), “Development and characterization of atorvastatin solid dispersion formulation using skimmed milk for improved oral bioavailability”, APSB, 2, 421-428.
Morishita M, Peppas NA. Advances in oral drug delivery: improved bioavailability of poorly absorbed drugs by tissue and cellular optimization. Preface. Adv Drug Deliv Rev. 2012; 64(6):479
Srinarong, P; Faber, JH; Visser, MR; Hinrichs, WLJ and Frijlink, HW (2009), “Strongly enhanced dissolution rate of fenofibrate solid dispersion tablets by incorporation of superdisintegrants”, Eur J Pharm Biopharm, 73, 154-161.
Vasconcelos T, Sarmento B. Costa P. Solid dispersions as strategy to improve oral bioavailability of poor water-soluble drugs. Drug discovery today. 2007; 12(23- 24):1068-1075.
Shah TJ, Amin AF, Parikh JR, Parikh RH. Process optimization and characterization of poloxamer solid dispersions of a poorly water-soluble drug. AAPS PharmSciTech. 2007;8(2): Article 29..
Remington, “The Science and Practice of Pharmacy”, 21st Ed., 687.
V. Tantishaiyakul, N. Kaewnopparatv and S. Ingkatawornwong. Properties of solid dispersions of piroxicam in polyvinylpyrrolidone. Int. J. Pharm. 1999; 181: 143-151.
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