A Review On : To Develop and Validate Analytical Method for Determination of Methimazole in Bulk and Pharmaceutical Dosage Form

Authors

  • Akankshsa S. Atole Shankarrao Ursal College of Pharmaceutical Sciences and Research Centre, Pune, Maharashtra, India Author
  • Payal S. Badhe Shankarrao Ursal College of Pharmaceutical Sciences and Research Centre, Pune, Maharashtra, India Author
  • Nilam H. Bavdhane Shankarrao Ursal College of Pharmaceutical Sciences and Research Centre, Pune, Maharashtra, India Author
  • Vijaya U. Barge Shankarrao Ursal College of Pharmaceutical Sciences and Research Centre, Pune, Maharashtra, India Author

DOI:

https://doi.org/10.32628/IJSRST24113248

Keywords:

Hyperthyroidism, Methimazole, C4H6N2S, Thyroperoxidase

Abstract

Hyperthyroidism is a condition characterized by increased in synthesis and secretion of thyroid hormones from thyroid gland. Methimazole is an anti-hyperthyroidism drug. It is of great importance and significance for life science. Up to now, various different methods have been applied for the determination of methimazole, such as spectrophotometry1-3, LC4, HPLC6, RP-HPLC7, HPLC-UV8, electrochemical analysis9, kinetic method10. In this paper, a new UV-Spectrophotometric method for the determination of methimazole has been established. The chemical name of Methimazole is (1-methylimidazole-2-thiol). The chemical formula of Methimazole is C4H6N2S and the molecular weight is 114.17 g/mol. The structure of Methimazole features a 5 membered imidazole ring with a methyl group at position 1st and thione group at position 2nd. Methimazole is white colour powder and has melting point 1440 C.

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Published

05-07-2024

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Section

Research Articles

How to Cite

[1]
Akankshsa S. Atole, Payal S. Badhe, Nilam H. Bavdhane, and Vijaya U. Barge , Trans., “A Review On : To Develop and Validate Analytical Method for Determination of Methimazole in Bulk and Pharmaceutical Dosage Form”, Int J Sci Res Sci & Technol, vol. 11, no. 4, pp. 05–14, Jul. 2024, doi: 10.32628/IJSRST24113248.