Distribution of Radiation Dosage to Organs at Risk (Oar) With Variations in Depth Brachytherapy Application in Cervical Cancer Patients
DOI:
https://doi.org/10.32628/IJSRST2411431Keywords:
Brachytherapy, Cervical Cancer, Applicator, Radiotherapy, OARAbstract
The accurate planning and selection of applicators are crucial in brachytherapy treatment to deliver radiation doses with high precision, ensuring maximum tumor targeting while minimizing doses to surrounding healthy organs. This study aims to evaluate the influence of changes in intrauterine applicator depth on the distribution of radiation doses in cervical cancer patients. Data were obtained from records of 30 patients undergoing brachytherapy treatment, comparing 10 patients with an initial applicator depth of 5 cm as a reference. The applicator depth was then adjusted to 4 cm and 6 cm through re-planning. Data analysis involved comparing average doses and calculating differences for each patient to determine the percentage change in applicator depth. Research findings indicate variations in radiation doses to organs at risk (OAR) concerning applicator depth. The highest average OAR doses occurred at a depth of 6 cm, while the lowest doses were at a depth of 4 cm. The difference in average doses at a 4 cm applicator depth was 2,49% for the bladder and 1,15% for the rectum. At a depth of 6 cm, the difference in average doses was 1,66% for the bladder and 1,72% for the rectum. The Wilcoxon signed-rank test (<0.05) revealed significant differences in doses between compared applicator depths.
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Global Cancer Statistics. 2020. GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. A Cancer Journal for Clinicians, 71(3), 209–249. DOI: https://doi.org/10.3322/caac.21660
Bhatla, N., Aoki, D., Sharma, D. N., & Sankaranarayanan, R. (2021). Cancer of the cervix uteri: 2021 update. International Journal of Gynecology and Obstetrics, 155(S1),28–44. https://doi.org/10.1002/ijgo.13865 DOI: https://doi.org/10.1002/ijgo.13865
Emilia, Ova, dkk. (2019). Bebas Ancaman Kanker Serviks. Jakarta: PT Elex Media Komputindo..
Puteri, A. P. (2020). "Karsinoma Serviks: Gambaran Radiologi dan Terapi Radiasi." RSUD Provinsi Nusa Tenggara Barat, Mataram, Indonesia.
Wu, A., Tang, D., Wu, A., Liu, Y., Qian, L., & Zhu, L. (2021). Comparison of the dosimetric influence of applicator displacement on 2d and 3d brachytherapy for cervical cancer treatment. Technology in Cancer Research & Treatment, 20, 15330338211041201. DOI: https://doi.org/10.1177/15330338211041201
Khan, A. A., Vijay, A., Wani, S. Q., & Haq, M. M. (2022a). Dosimetric analysis of intracavitary brachytherapy applicators: a practical study. Journal, Radiation 40(3), Oncology 180–191. https://doi.org/10.3857/roj.2022.00199. DOI: https://doi.org/10.3857/roj.2022.00199
Subroto, R., Setiawati, E., & Suwardi, D. (2013). Analisis Pengaruh Perubahan Sentrasi Dosis dan Jarak Bladder Terhadap Distribusi Dosis Pada Perencanaan Brachytherapy Kanker Serviks. In Youngster Physics Journal, Vol. 1, Issue 4.
Glaser, S. M., Mohindra, P., Mahantshetty, U., & Beriwal, S. (2021). Complications of intracavitary brachytherapy for gynecologic cancers and comprehensive 20(5), 984-994.
Glaser, S. M., Mohindra, P., Mahantshetty, U., & Beriwal, S. (2021). Complications of intracavitary brachytherapy for gynecologic cancers and comprehensive 20(5), 984-994. DOI: https://doi.org/10.1016/j.brachy.2020.11.011
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