A Systematic Review of Triphala Churna: A Focus on Ingredient Synergism and its Implications for Human Health

Authors

  • Mayuresh Joshi Assistant Professor, Department of Life Sciences, Kishinchand Chellaram College, HSNC University, Mumbai- 400020, Maharashtra, India Author
  • Prerna Khanchandani Department of Life Sciences, Kishinchand Chellaram College, HSNC University, Mumbai, Maharashtra, India Author

DOI:

https://doi.org/10.32628/IJSRST24114329

Keywords:

Triphala churna, Review Article, Therapeutic potential, uses, Ingredients

Abstract

Triphala Churna, a revered Ayurvedic formulation, has gained global recognition for its multifaceted health benefits. This review delves into the traditional uses and modern scientific evidence supporting the therapeutic potential of Triphala Churna and its constituent fruits: Amalaki (Emblica officinalis), Bibhitaki (Terminalia bellirica), and Haritaki (Terminalia chebula). Amalaki, rich in vitamin C and antioxidants, exhibits potent anti-inflammatory and immune-boosting properties. Bibhitaki possesses anti-inflammatory, antimicrobial, and hepatoprotective actions. Haritaki demonstrates laxative, anti-diabetic, and anti-inflammatory effects. These synergistic interactions among the ingredients contribute to the wide range of pharmacological activities observed with Triphala Churna, including improved digestion, enhanced immunity, antioxidant protection, and support for various chronic diseases. The growing body of scientific research validates the traditional claims of Triphala Churna, solidifying its position as a valuable therapeutic agent in the realm of herbal medicine. As interest in natural and integrative approaches to healthcare continues to rise, Triphala Churna holds immense potential to contribute to global wellness by offering a safe and effective alternative or complementary therapy for various health conditions. This current review comprehensively summarizes the therapeutic potential of Triphala Churna and its ingredients, providing a valuable foundation for future research and clinical applications.

Downloads

Download data is not yet available.

References

A. Uttpal, C. K. Tadu, S. Nandy, S. Kumari, V. Tripathi, G. J. Loake, A. Dey and P. Jaroslaw, “Ethnodermatological use of medicinal plants in India: From ayurvedic formulations to clinical perspectives – A review,” Journal Of Ethnopharmacology, vol. 284, p. 114744, 2022. DOI: https://doi.org/10.1016/j.jep.2021.114744

B. Parveen, A. Parveen, R. Parveen , S. Ahmed, M. Ahmad and M. Iqbal, “Challenges and opportunities for traditional herbal medicine today with special reference to its status in India,” Annals of Phytomedicine, vol. 9, no. 2, pp. 97 - 112, 2020. DOI: https://doi.org/10.21276/ap.2020.9.2.8

U. Forest Service, “U. S. Forest Service, United States Department of Agriculture,” 2023. [Online]. Available: https://www.fs.usda.gov/wildflowers/ethnobotany/medicinal/. [Accessed 24 06 2023].

H. Yuan, Q. Ma, L. Ye and G. Piao, “The traditional medicine and modern medicine from natural products,” Molecules, vol. 21, no. 5, p. 559, 2016. DOI: https://doi.org/10.3390/molecules21050559

B. Chouhan, R. C. Kumawat, M. Kotecha, A. Ramamurthy and S. Nathani, “Triphala: A Comprehensive Ayurvedic Review,” International Journal of Research in Ayurveda and Pharmacy, vol. 4, no. 4, pp. 612 - 617, 2013. DOI: https://doi.org/10.7897/2277-4343.04433

A. A. Lakshmi, R. K. Jat and E. N. Siju, “Triphala: Its Pharmacological Values and New Prospective,” World Journal of Advanced Research and Reviews, vol. 16, no. 02, pp. 654 - 659, 2022. DOI: https://doi.org/10.30574/wjarr.2022.16.2.1210

C. T. Peterson, K. Denniston and D. Chopra, “Therapeutic Uses of Triphala in Ayurvedic Medicine,” The Journal of Alternative and Complementary Medicine, vol. 23, no. 8, pp. 607 - 614, 2017.

S. Sivashankar, R. lavanya, P. Brindha and N. Angayakanni, “Aqueous and alcoholic extracts of Triphala and their active compounds chebulagic acid and chebulinic acid prevented epithelial to mesenchymal transition in retinal pigment epithelial cells, by inhibiting SMAD-3 phosphorylation,” PLoS One, vol. 10, no. 3, p. e0120512, 2015. DOI: https://doi.org/10.1371/journal.pone.0120512

C. T. Peterson, K. Denniston and D. Chopra, “Therapeutic Uses of Triphala in Ayurvedic Medicine,” Journal of Alternative and Complementary Medicine, vol. 23, no. 8, pp. 607 - 614, 2017. DOI: https://doi.org/10.1089/acm.2017.0083

B. P. Gaire and L. Subedi, “Phytochemistry, pharmacology and medicinal properties of Phyllanthus emblica Linn.,” Chinese Journal Of Integrative Medicine, vol. 2014, p. Online, 2014. DOI: https://doi.org/10.1007/s11655-014-1984-2

A. T. Prananda, A. Dalimunthe, U. Harahap and et al.,, “Phyllanthus emblica: a comprehensive review of its phytochemical composition and pharmacological properties,” Frontiers in pharmacology, vol. 14, 2023. DOI: https://doi.org/10.3389/fphar.2023.1288618

G. Li, Q. Yu, N. Li, D. Zhang and J. Yu, “Phyllanthus emblica fruits: a polyphenol-rich fruit with potential benefits for oral management,” Food and Function, vol. 14, pp. 7738 - 7759, 2023. DOI: https://doi.org/10.1039/D3FO01671D

R. Saini, V. Kumar, A. Sourirajan and A. Dev, “Fruit Extract and Phenolic Compounds of Phyllanthus emblica Fruits as Bioactivity Enhancer of Chloramphenicol Against Bacterial Species,” Plant food ffor Human Nutrition, vol. 79, pp. 656 - 661, 2024. DOI: https://doi.org/10.1007/s11130-024-01206-6

A. G. Pawar, Hamid, R. Shams, K. K. Dash, A. M. Shakj, D. Ungai, r. Harsanyi and t. Suthar, “Recent Insights into the Morphological, Nutritional and Phytochemical Properties of Indian Gooseberry (Phyllanthus emblica) for the Development of Functional Foods,” plants, vol. 13, no. 5, pp. 574 - 5900, 2024. DOI: https://doi.org/10.3390/plants13050574

E. Geethika, S. Ramamoorthy and G. Ravikanth, “Phyllanthus emblica and Phyllanthus indofischeri: Wild Fruits with Multifarious Uses,” Fruits and Nut Crops, vol. Springer Nature References, pp. 1 - 18, 2023. DOI: https://doi.org/10.1007/978-981-99-1586-6_19-1

E. Singh, S. Sharma, A. Pareek, J. Dwivedi, S. Yadav and S. Sharma, “Phytochemistry, traditional uses and cancer chemopreventive activity of Amla (Phyllanthus emblica): The Sustainer,” Journal of Applied Pharmaceutical Science, vol. 2, no. 1, pp. 176 - 183, 2011.

K. H. Khan, “Roles of Emblica officinalis in medicine-A review,” Botany Research International , vol. 2, no. 4, pp. 218 - 228, 2009.

T. Zhao, Q. Sun, M. Marques and M. Witcher, “Anticancer Properties of Phyllanthus emblica (Indian Gooseberry),” Oxidative Medicine and Cellular Longevity, vol. 2015, pp. 1-7, 2015. DOI: https://doi.org/10.1155/2015/950890

D. W. Unander, G. L. Webster and B. S. Bllumberg, “Records of usage or assays in Phyllanthus (Euphorbiaceae) I. Subgenera Isocladus, Kirganelia, Cicca and Emblica,” Journal O4Ethnopharmacology, vol. 30, no. 3, pp. 233 - 2674, 1990. DOI: https://doi.org/10.1016/0378-8741(90)90105-3

S. Nambiar, M. Paramesha and N. Shetty, “Comparative analysis ofphytochemical profile, antioxidant activities and foam prevention abilitiesof whole fruit, pulp and seeds of Emblica officinalis,” Journal of Food Science and Technology, vol. 52, no. 11, pp. 7254 - 7262, 2015. DOI: https://doi.org/10.1007/s13197-015-1844-x

G. J. Bhatia, S. Ojha and D. S. Arya, “Hydroalcoholic extract of Emblica officinalis protects against kainic acid-induced status epilepticus in rats:evidence for an antioxidant, anti-inflammatory, and neuroprotective intervention,,” Pharmacology and Biology, vol. 49, no. 11, pp. 1128 - 1136, 2011. DOI: https://doi.org/10.3109/13880209.2011.571264

M. Golechha, V. Sarangal, S. Ojha, J. Bhatia and D. S. Arya, “Anti-inflammatory effect of Emblica officinalis in rodent models of acute and chronic inflammation: involvement of possible mechanisms,” International Journal of Inflammation, vol. 2014, p. 178408, 2014. DOI: https://doi.org/10.1155/2014/178408

B. Variya, A. Bakrania and S. Patel, “Emblica officinalis (Amla): A review for its phytochemistry, ethnomedicinal uses and medicinal potentials with respect to molecular mechanisms,” Pharmacological Research, vol. 111, no. 2016, pp. 180-200, 2016. DOI: https://doi.org/10.1016/j.phrs.2016.06.013

G. Das, D. Kim, C. Fan, B. J. Heredia and et al.,, “Plants of the Genus Terminalia: An Insight on Its Biological Potentials, Pre-Clinical and Clinical Studies,” Frontiers in Pharmacology, vol. 11, no. 2020, p. e journal, 2020. DOI: https://doi.org/10.3389/fphar.2020.561248

I. E. Cock, “The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae),” Inflammopharmacology, vol. 23, pp. 203 - 229, 2015. DOI: https://doi.org/10.1007/s10787-015-0246-z

M. Chopra , G. Deswal, B. Chopra, P. Kriplani and R. Dass, “Therapeutic and Health Promoting Potential of Terminalia chebula: An Exploratory Literature Review,” Currente Traditional Medicine, vol. 10, no. 7, pp. 55 - 77, 2024. DOI: https://doi.org/10.2174/2215083810666230815142547

M. Tiwari and M. S. Barooah, “A comprehensive review on the ethno-medicinal and pharmacological properties of Terminalia chebula fruit,” Phytochemistry Reviews, vol. 23, pp. 125 - 145, 2023.

R. Sehgal, A. K. Sharma, B. J. Singh, R. V. Saini, A. K. Saini and V. Beniwal, “Augmenting the antioxidant, anti-bacterial and anti-carcinogenic potential of Terminalia chebula and Terminalia bellirica after tannin acyl hydrolase mediated biotransformation,” Biocatalysis and Agricultural Biotechnology, vol. 56, no. 204, p. 103045, 2024. DOI: https://doi.org/10.1016/j.bcab.2024.103045

H. L. Kim, B. Choi and S. H. Yang, “Terminalia chebula Medicinal Uses: A Review of in vitro and in vivo Studies,” Biotechnology and Bioprocess Engineering, vol. 27, pp. 729 - 739, 2022. DOI: https://doi.org/10.1007/s12257-022-0090-0

M. Tiwari and M. S. Barooah, “A comprehensive review on the ethno-medicinal and pharmacological properties of Terminalia chebula fruit,” Phytochemistry Reviews, vol. 23, pp. 125 - 145, 2023. DOI: https://doi.org/10.1007/s11101-023-09878-9

M. T. Sulltan, M. J. Anwara, M. Imran, I. Khalil, F. Saeed and S. Neelum, “Phytochemical profile and pro-healthy properties of Terminalia chebula: A comprehensive review,” International Journal of Food Properties, vol. 26, no. 1, pp. 526 - 551, 2023. DOI: https://doi.org/10.1080/10942912.2023.2166951

P. Poudel, R. Thapa, S. Lamicchane, H. R. Paudel and H. P. Devkota, “Chapter 40 - Terminalia chebula Retz.,” in Himalayan Fruits and Berries; Bioactive Compounds, Uses and Nutraceutical Potential, T. Belwel , I. Bhatt and H. Devkota, Eds., Academic Press, 2023, pp. 435 - 449. DOI: https://doi.org/10.1016/B978-0-323-85591-4.00015-5

S. B. Manjeshwar, M. Sharaka, M. Benson, P. R. Manoj, P. Vikas and L. P. Princy, “Scientific validation of the ethnomedicinal properties of the Ayurvedic drug Triphala: A review,” Chinese Journal of Integrative Medicine , vol. 18, pp. 946 - 954, 2012. DOI: https://doi.org/10.1007/s11655-012-1299-x

P. Ankita, B. Anindya, G. Bhavna, P. Milan, I. Asif, B. Swati and A. Manoranjan, “Development of Triphala Churna extract mediated iron oxide nanoparticles as novel treatment strategy for triple negative breast cancer,” Journal of Drug Delivery Science and Technology , vol. 76, no. 2022, p. 103735, 2022. DOI: https://doi.org/10.1016/j.jddst.2022.103735

S. J. Gaikwad, P. Rao and D. N. Vikhe, “A Review on Standardization Of Patnanjali Triphala Churna,” World Journal of Pharmaceutical Research, vol. 9, no. 7, pp. 1305 - 1320, 2020.

S. A. Chandran, A. A. Prabhakaran, J. S. Sasikumar and R. Perumana, “Multiple Targets Directed Multiple Ligands: An In Silico and In Vitro Approach to Evaluating the Effect of Triphala on Angiogenesis,” Biomolecules , vol. 10, no. 2, pp. 177 - 190, 2020. DOI: https://doi.org/10.3390/biom10020177

Downloads

Published

27-12-2024

Issue

Section

Research Articles

How to Cite

A Systematic Review of Triphala Churna: A Focus on Ingredient Synergism and its Implications for Human Health . (2024). International Journal of Scientific Research in Science and Technology, 11(6), 791-800. https://doi.org/10.32628/IJSRST24114329

Similar Articles

1-10 of 195

You may also start an advanced similarity search for this article.