A Thrilling Case of Anemia

Mohammed Shanil P; Farsana Jasmin K

doi:10.32628/IJSRST2411493

Authors

Mohammed Shanil P DM Cardiology Resident, Government medical college, Kannur Kerala, India Author https://orcid.org/0000-0002-2001-3912
Farsana Jasmin K MD Radiotherapy Resident, Government medical college, Kozhikode, India Author

DOI:

https://doi.org/10.32628/IJSRST2411493

Keywords:

Paroxysmal Nocturnal Hemoglobinuria, Glycosylphosphatidylinositol, Eculizumab, Ravulizumab, Pegcetacoplan

Abstract

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare bone marrow failure disorder that presents with triad of peripheral blood cytopenias, hemolytic anemia and thrombosis. The absence of two glycosylphosphatidylinositol (GPI)-anchored proteins, CD55 and CD59, leads to uncontrolled complement activation that accounts for hemolysis and other PNH manifestations. GPI anchor protein deficiency is due to acquired somatic mutations in phosphatidylinositol glycan class A (PIGA) gene.Terminal complement inhibition with eculizumab and allogeneic bone marrow transplantation (BMT) are the only widely effective therapies for patients with classical PNH. Compared to eculizumab and ravulizumab that block the fifth component of complement (C5), pegcetacoplan blocks the third component of complement (C3).

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References

Moraes de Moraes MP, Salomão RPA, Felício AC, Abrantes FF, Barsottini OGP, Pedroso JL. Reversible Acute Parkinsonism and Unusual Neuroimaging Findings in Systemic Lupus Erythematosus. Mov Disord Clin Pract. 2020 Apr 7;7(4):459-461. doi: 10.1002/mdc3.12943 DOI: https://doi.org/10.1002/mdc3.12943

Romba M, Wang Y, Hu SC, Khot S. Jaw dystonia and reversible basal ganglia changes as an initial presentation of systemic lupus erythematosus. The Neurohospitalist. 2018 Jan;8(1):31-4 DOI: https://doi.org/10.1177/1941874417698323

B. Nemade, J. Nair, and B. Nemade, "Efficient GDP Growth Forecasting for India through a Novel Modified LSTM Approach," Communications on Applied Nonlinear Analysis, vol. 31, no. 2s, pp. 339-357, 2024. DOI: https://doi.org/10.52783/cana.v31.653

B. Marakarkandy, B. Nemade, S. Kelkar, P. V. Chandrika, V. A. Shirsath, and M. Mali, "Enhancing Multi-Channel Consumer Behavior Analysis: A Data-Driven Approach using the Optimized Apriori Algorithm," Journal of Electrical Systems, vol. 20, no. 2s, pp. 700–708, 2024. DOI: https://doi.org/10.52783/jes.1536

Patil, P., Kataria, B., Redkar, V., Banait, A., Shilpa, C., Patil, & Khetani, V. (08 2024). Automated Detection of Tuberculosis Using Deep Learning Algorithms on Chest X-rays. Frontiers in Health Informatics, 13, 218–229. https://healthinformaticsjournal.com/index.php/IJMI/article/view/20

Wantaneeyawong C, Kasitanon N, Kumchana K, Louthrenoo W. Acute parkinsonism in patients with systemic lupus erythematosus: a case report and review of the literature. Int J Neurosci. 2022 Sep;132(9):868-873. doi: 10.1080/00207454.2020.1847106 DOI: https://doi.org/10.1080/00207454.2020.1847106