Antibacterial activity of Novel PCMX Derivatives
DOI:
https://doi.org/10.32628/IJSRST241161114Keywords:
Parachlorometaxylenol, antibacterial, antiseptic, disinfectant, 1HNMR, ester molecule, Gram positive, Gram negative, bacterial culturesAbstract
Chloroxylenol, or Parachlorometaxylenol (PCMX), is an antiseptic and disinfectant agent used for skin disinfection and surgical instruments. It is found in antibacterial soaps, wound-cleansing applications, and household antiseptics. Its analogues viz. Ethers, esters and hybrid derivatives also possess various biological activities which prompted us to synthesize a novel analogue for future application as bioactive molecule. These synthesized compounds were tested against certain Gram positive and Gram negative bacterial strains to evaluate their potential antibacterial activity.
Downloads
References
Wattenberg L. W., Coccia J. B.,Lam L. K. Inhibitory effects of phenolic compounds on benzo(a)pyrene-induced neoplasia. Cancer Res., 1980, 40, pp. 2820 – 2823.
Talalay P., De Long M. U., Prochaska H. J. Identification of a common chemical signal regulating the induction of enzymes that protects against chemical carcinogenesis. Proc. Natl. Acad. Sci. USA.
Macheix JJ., Fleuriet A.;Billot J. Fruit phenolics. Boca Raton, FL; CTC; 1990.
World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 324. hdl:10665/44053. ISBN 9789241547659.
Griffiths, Christopher; Barker, Jonathan; Bleiker, Tanya; Chalmers, Robert; Creamer, Daniel (2016-02-29). Rook's Textbook of Dermatology, 4 Volume Set. John Wiley & Sons. p. 128.38. ISBN 9781118441176. Archived from the original on 2017-01-13.
Gangan V. D., Yadav U, Mewada K., Khandait S. A., Parulekar T. P., Singh A., Raddi K. Ester Derivatives of eugenol as potential Antibacterial agent. International journal of food and nutritional sciences, 2022, UGC Care listed Journal (Group I), Vol. 11 (10), pp. 2818 – 2825.
Parulekar T. P. and Gangan V. D. et. al. Ester Derivative of PCMX as Potential Antibacterial Agent. International Journal of Scientific Research in Science and Technology, November – December 2023, 10 (6), pp. 65 – 70. DOI: https://doi.org/10.32628/IJSRST52310613
Parulekar T. P. and Gangan V. D. et al. Synthesis and Antibacterial Activity of PCMX Derivative. International Journal for Research in Applied Science and Engineering Technology (IJRASET), January 2024, Vol. 12 ( 1 ), pp. 585 – 589. DOI: https://doi.org/10.22214/ijraset.2024.57998
Parulekar T. P. and Gangan V. D.Synthesis of Novel PCMX derivative. International Journal of Research in Science and Technology, Sept. – Oct. 2024, Vol. 11 (5), pp. 01 – 04 and the references cited therein. DOI: https://doi.org/10.32628/IJSRST24114145
Mahmoud A. M., Salem O. I., Abdel Moty, S. G. and Abdel Alim A. M.. Synthesis and Antimicrobial Evaluation of Some New Thiazoline and Thiazolidinone Derivatives Incorporating [1,2,4]Triazolo[1,5-a]benzimidazole. Indian journal of pharmaceutical sciences, 2013, 75 (5), pp. 545 - 556.
Yadav M. K. and Tiwari, S. K. Methods for Determination of Antimicrobial Activity of Bacteriocins of Lactic Acid Bacteria. Microbiology, 2023, 92, pp. 745 - 765 and the references cited therein. DOI: https://doi.org/10.1134/S0026261723600520
Manandhar S., Luitel S. and Dahal R. K. In Vitro Antimicrobial Activity of Some Medicinal Plants against Human Pathogenic Bacteria. Journal of tropical medicine, 2019, pp. 1 - 6.. https://doi.org/10.1155/2019/1895340 DOI: https://doi.org/10.1155/2019/1895340
Downloads
Published
Issue
Section
License
Copyright (c) 2024 International Journal of Scientific Research in Science and Technology
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
