Antibacterial activity of Novel PCMX Derivatives

Authors

  • Tanuja P. Parulekar Department of Chemistry, S.I.W.S. N.R. Swamy College of Commerce & Economics and Smt. Thirumalai College of Science, Wadala, Mumbai-400031, Maharashtra, India Author
  • Ajitha S. Nair Department of Microbiology, S.I.W.S. N.R. Swamy College of Commerce & Economics and Smt. Thirumalai College of Science, Wadala, Mumbai-400031, Maharashtra, India Author
  • Vijay D. Gangan Department of Chemistry, Reena Mehta College of Arts, Commerce, Science and Management Studies, Bhayandar (W), Thane – 401107, Maharashtra, India Author

DOI:

https://doi.org/10.32628/IJSRST241161121

Keywords:

Parachlorometaxylenol, antibacterial, antiseptic, disinfectant, 1HNMR, ester molecule, Gram positive, Gram negative, bacterial cultures

Abstract

Chloroxylenol, or Parachlorometaxylenol (PCMX), is an antiseptic and disinfectant agent used for skin disinfection and surgical instruments. It is found in antibacterial soaps, wound-cleansing applications, and household antiseptics. Its analogues viz. Ethers, esters and hybrid derivatives also possess various biological activities which prompted us to synthesize a novel analogue for future application as bioactive molecule. These synthesized compounds were tested against certain Gram positive and Gram negative bacterial strains to evaluate their potential antibacterial activity.

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References

Wattenberg L. W., Coccia J. B.,Lam L. K. Inhibitory effects of phenolic compounds on benzo(a)pyrene-induced neoplasia. Cancer Res., 1980, 40, pp. 2820 – 2823.

Talalay P., De Long M. U., Prochaska H. J. Identification of a common chemical signal regulating the induction of enzymes that protects against chemical carcinogenesis. Proc. Natl. Acad. Sci. USA.

Macheix JJ., Fleuriet A.;Billot J. Fruit phenolics. Boca Raton, FL; CTC; 1990.

World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 324. hdl:10665/44053. ISBN 9789241547659.

Griffiths, Christopher; Barker, Jonathan; Bleiker, Tanya; Chalmers, Robert; Creamer, Daniel (2016-02-29). Rook's Textbook of Dermatology, 4 Volume Set. John Wiley & Sons. p. 128.38. ISBN 9781118441176. Archived from the original on 2017-01-13.

Gangan V. D., Yadav U, Mewada K., Khandait S. A., Parulekar T. P., Singh A., Raddi K. Ester Derivatives of eugenol as potential Antibacterial agent. International journal of food and nutritional sciences, 2022, UGC Care listed Journal (Group I), Vol. 11 (10), pp. 2818 – 2825.

Parulekar T. P. and Gangan V. D. et. al. Ester Derivative of PCMX as Potential Antibacterial Agent. International Journal of Scientific Research in Science and Technology, November – December 2023, 10 (6), pp. 65 – 70.

Parulekar T. P. and Gangan V. D. et al. Synthesis and Antibacterial Activity of PCMX Derivative. International Journal for Research in Applied Science and Engineering Technology (IJRASET), January 2024, Vol. 12 ( 1 ), pp. 585 – 589.

Parulekar T. P. and Gangan V. D.Synthesis of Novel PCMX derivative. International Journal of Research in Science and Technology, Sept. – Oct. 2024, Vol. 11 (5), pp. 01 – 04 and the references cited therein.

Mahmoud A. M., Salem O. I., Abdel Moty, S. G. and Abdel Alim A. M.. Synthesis and Antimicrobial Evaluation of Some New Thiazoline and Thiazolidinone Derivatives Incorporating [1,2,4]Triazolo[1,5-a]benzimidazole. Indian journal of pharmaceutical sciences, 2013, 75 (5), pp. 545 - 556.

Yadav M. K. and Tiwari, S. K. Methods for Determination of Antimicrobial Activity of Bacteriocins of Lactic Acid Bacteria. Microbiology, 2023, 92, pp. 745 - 765 and the references cited therein.

Manandhar S., Luitel S. and Dahal R. K. In Vitro Antimicrobial Activity of Some Medicinal Plants against Human Pathogenic Bacteria. Journal of tropical medicine, 2019, pp. 1 - 6.. https://doi.org/10.1155/2019/1895340

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Published

15-03-2025

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Section

Research Articles

How to Cite

Antibacterial activity of Novel PCMX Derivatives. (2025). International Journal of Scientific Research in Science and Technology, 12(2), 284-290. https://doi.org/10.32628/IJSRST241161121

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