Current Advancements in Dendrimer Technology in Cancer Therapy

Authors

  • N. Madhavi Department of Pharmaceutics, CMR College of Pharmacy, Medchal, Kandlakoya, Hyderabad-501401, Telangana, India Author
  • K. Nikhila Department of Pharmaceutics, CMR College of Pharmacy, Medchal, Kandlakoya, Hyderabad-501401, Telangana, India Author
  • Y. Laxmi Prasanna Department of Pharmaceutics, CMR College of Pharmacy, Medchal, Kandlakoya, Hyderabad-501401, Telangana, India Author
  • B. Keerthi Department of Pharmaceutics, CMR College of Pharmacy, Medchal, Kandlakoya, Hyderabad-501401, Telangana, India Author
  • T. Rama Rao Department of Pharmaceutics, CMR College of Pharmacy, Medchal, Kandlakoya, Hyderabad-501401, Telangana, India Author

DOI:

https://doi.org/10.32628/IJSRST25121155

Keywords:

Dendrimer, Liposomes, Nanotechnology, Cancer, Size

Abstract

Cancer is a leading cause of death worldwide, and the main treatment methods for this condition are surgery, chemotherapy, and radiotherapy.Over the past forty years, dendrimer research has expanded rapidly, from synthesis to applications because of their unique structural features such as their nanoscopic size, multifunctionalized surface, high branching etc., Hence the current review article mainly focused to explore the history, characteristics, impact of dendrimers in nanotechnology, role of dendrimer nano-carriers in cancer treatment with and recent advancements of dendrimers as drug delivery vehicles.

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References

Xintao Yan et al. J. Phys.: Conf. Ser. 2021. 1948. 012205. DOI: https://doi.org/10.1088/1742-6596/1948/1/012205

Saviour A. Umoren, Viswanathan S. Saji. Polymeric Materials in Corrosion Inhibition, 2022. pp.: 467-488. DOI: https://doi.org/10.1016/B978-0-12-823854-7.00016-3

Klajnert B, Bryszewska M. Dendrimers: properties and applications. ActaBiochim Pol. 2001;9:199–208. DOI: https://doi.org/10.18388/abp.2001_5127

Tomalia DA, Frechet JMJ. Discovery of dendrimers and dendritic polymers: a brief historical perspective. J PolymSci A Polym Chem. 2002; 9:2719–2728. DOI: https://doi.org/10.1002/pola.10301

Tomalia DA. The dendritic state. Mater Today. 2005;9:34–36. DOI: https://doi.org/10.1016/S1369-7021(05)00746-7

Tomalia DA, et al. A new class of polymers: starburst dendritic polymers. Polymers for Advanced Technologies, 1985; 6(2): 1-5. DOI: https://doi.org/10.1295/polymj.17.117

Meyer M, et al. Dendrimers in Drug Delivery: Current Applications and Future Perspectives. Pharmaceutics. 2020; 12(5): 460.

Kumar R. et al. Dendrimers in cancer therapy: A review. Journal of Controlled Release. 2017; 263: 1-18.

Saha S. et al. Dendrimers for targeted drug delivery in cancer therapy. Biotechnology Advances. 2020; 38: 107371.

Khang S. et al. Dendrimers as immunotherapeutic agents. Trends in Biotechnology, 2022; 40(9): 993-1008.

Gupta U. et al. Clinical translation of dendrimer-based therapies. Biomaterials Science. 2019; 7(10): 4021-4035.

Kakkar A. et al. Dendrimers: A new class of nanomaterials. Advances in Colloid and Interface Science. 2018; 148: 66-74.

Barenholz Y. Doxil® the first FDA-approved nano-drug: Lessons learned. Nature Reviews Drug Discovery. 2009; 9(1): 51-51.

Maiti K. et al. Dendritic polymers in biomedical applications. Chemical Society Reviews. 2011; 40(3): 1609-1619.

Harris JM & Chess RB. Effect of pegylation on pharmaceuticals. Nature Reviews Drug Discovery. 2003;2(3): 214-221. DOI: https://doi.org/10.1038/nrd1033

Frechet JMJ. Dendritic polymers: from design to applications. Science. 1994; 263(5154): 1710-1715. DOI: https://doi.org/10.1126/science.8134834

Kuehne AJC. et al. Dendritic Polymers: The New Macromolecules for Bio-Applications. Macromolecular Rapid Communications. 2015; 36(18): 1623-1641.

Barenholz Y. Doxil®-The First FDA-Approved Nano-Drug: Lessons Learned. Nature Reviews Drug Discovery. 2012; 9(1): 47-57.

Panyam J & Dali S. Dendrimers for Drug Delivery. Advanced Drug Delivery Reviews. 2005; 57(15): 2155-2170. DOI: https://doi.org/10.1016/j.addr.2005.09.017

Reddy MM. et al. Dendritic Polymers as Multi-Functional Platforms for Drug Delivery. Journal of Drug Targeting. 2007; 15(9): 655-667.

Wang Y. et al. Biocompatibility of Dendrimers. Molecular Pharmaceutics. 2013;10(3): 1068-1076.

Merdan T. et al. Dendritic Polymers for Gene Delivery. Advanced Drug Delivery Reviews, 2002; 54(4): 583-604. DOI: https://doi.org/10.1016/S0169-409X(02)00046-7

Voros J. et al. Dendritic polymers for targeted drug delivery in cancer therapy. Bio-macromolecules, 2020; 21(3): 1125-1138.

Ranjan SK. et al. Dendrimers in cancer therapy: Potential and challenges. Journal of Controlled Release. 2021; 331: 233-249.

Dufes C. et al. Dendrimers as carriers for the delivery of therapeutics and imaging agents. Journal of Nanobiotechnology. 2019; 17: 65.

Chen H. et al. Dendrimers for cancer therapy: Strategies and challenges. Molecular Pharmaceutics. 2018; 15(9): 3666-3677.

Wong YS. et al. Dendrimers in cancer therapy: A comprehensive review. Advanced Drug Delivery Reviews. 2022; 178: 113853.

Patel S. et al. Polymeric nanoparticles in cancer therapy. Pharmaceutical Research. 2019; 36(2): 1-19.

Gabizon A. et al. Liposomes as a drug delivery system: new directions in cancer therapy. Clinical Cancer Research. 2003; 9(15): 5001-5005.

Ranjan R. et al. Dendrimers: A potential carrier for targeted drug delivery in cancer therapy. Current Pharmaceutical Design. 2017; 23(14): 2072-2083.

Zhang L. et al. Micelles in cancer therapy: a review. Journal of Controlled Release. 2013; 169(2): 192-201.

Zhao J. et al. Silica nanoparticles for drug delivery in cancer therapy. Journal of Nanoscience and Nanotechnology. 2015; 15(1): 263-278.

Chiocca. EA. et al. Oncolytic viruses for cancer therapy: a review. Nature Reviews Clinical Oncology. 2015;12(5): 270-285.

Wang Y. et al. Exosomes in cancer therapy: potential applications. Journal of Cancer Research and Clinical Oncology. 2019; 145(1): 1-10.

Kumar A. et al. Liposomal dendrimer systems for cancer therapy: A review. Journal of Controlled Release. 2020; 321: 485-502.

Sharma P. et al. Nanocarrier systems: Liposomes and dendrimers for effective anticancer drug delivery. Nanomedicine. 2021; 16(5): 435-450.

Rathi V. et al. Targeted liposome-dendrimer hybrid systems for enhanced cancer therapy. Biomaterials Science. 2022; 10(3): 727-740.

Singh R. et al. Advancements in liposome-dendrimer technologies for cancer treatment. Current Drug Delivery. 2023; 20(4): 559-575.

Gupta S. et al. Formulation and characterization of liposome-dendrimer systems for cancer therapy. International Journal of Pharmaceutics. 2023; 624: 122108.

Nair A. et al. Niosomes: A novel approach for drug delivery in cancer therapy. Journal of Drug Delivery Science and Technology. 2021; 61: 102164.

Yadav M. et al. Niosomes and dendrimers: Emerging trends in cancer therapy. Asian Journal of Pharmaceutical Sciences. 2020; 15(6): 707-719.

Sahni J. et al. Targeted delivery of anticancer drugs using dendrimer-niosomes. Current Drug Delivery. 2022; 19(1): 19-32.

Jaiswal S. et al. Recent advancements in niosome-dendrimer hybrid systems for cancer treatment. International Journal of Pharmaceutics. 2023; 609: 121183.

Patel S. et al. Exploring niosomes and dendrimers in cancer drug delivery. Pharmaceutical Research, 2023; 40: 135-148.

El Maghraby GM. et al. Ethosomes: A novel drug delivery system. Drug Delivery. 2008; 15(7): 397-406.

Khan Y. et al. Nanocarriers for the delivery of anticancer drugs: Recent developments and future perspectives. Journal of Drug Delivery Science and Technology. 2020; 55: 101467.

Kumar R. et al. Dendrimers in cancer therapy: A review. Journal of Drug Delivery Science and Technology. 2019; 52: 167-181.

Mishra R. et al. Recent advances in dendrimer-based drug delivery systems for cancer therapy. Nanomedicine: Nanotechnology, Biology and Medicine. 2018; 14(1): 81-93.

Nunes C. et al. Advances in the use of dendrimers and ethosomes for the delivery of anticancer agents. Pharmaceutics. 2021; 13(6): 860.

Zhao H. et al. Exosomes and dendrimers: A novel approach for targeted cancer therapy. Journal of Nanobiotechnology. 2022; 20: 123.

Lopez-Verdin S. et al. Combining dendrimers and exosomes for enhanced drug delivery in cancer treatment. Pharmaceutical Research 2021; 38: 678-691.

Chen Q. et al. Functionalized dendrimer-exosome hybrid systems for targeted therapy. Nanomedicine: Nanotechnology. Biology and Medicine. 2023; 43: 102513.

Jiang Y. et al. Innovations in exosome-dendrimer technology for cancer therapeutics. Molecular Therapy. 2023; 31(2): 467-482.

Zhang Y. et al. Recent advances in exosome-dendrimer systems for drug delivery in cancer therapy. International Journal of Pharmaceutics. 2023; 614: 121412.

Bender JE. et al. Folate-Functionalized Dendrimers for Targeted Drug Delivery. Molecules. 2017; 22(10): 1633.

Purohit S. et al. Dendrimers in gene therapy: recent advancements. Journal of Nanobiotechnology. 2012; 10(1): 2.

Liao Z. et al. Dendrimers as vaccine carriers: A review. International Journal of Nanomedicine. 2013; 8: 1741-1750.

Banerjee S. et al. Dendrimers in cancer drug delivery. Journal of Drug Delivery Science and Technology. 2014; 24(1): 62-70.

Khan Y. et al. Dendrimers for antibiotic delivery. Molecular Pharmaceutics. 2016; 13(7): 2085-2096.

Hwang SK. et al. Dendritic polymer systems for small molecule delivery. Journal of Controlled Release, 2015; 202: 52-68.

McCarthy DE. et al. Dendrimers for siRNA delivery. Molecular Pharmaceutics, 2011; 8(4): 1165-1174.

Karpagam S, et al. Dendrimers in antiviral drug delivery. Current Drug Metabolism. 2019; 20(5): 389-400.

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Published

08-01-2025

Issue

Section

Research Articles

How to Cite

Current Advancements in Dendrimer Technology in Cancer Therapy. (2025). International Journal of Scientific Research in Science and Technology, 12(1), 55-66. https://doi.org/10.32628/IJSRST25121155

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