Geosciences Fina Public Health: Geochemical Variables as Causal Co-Factor Diseases of Unknown Aetiology in the Dynamic and Highly Evolving Environment
DOI:
https://doi.org/10.32628/IJSRST25121171Keywords:
Metals, Geoscience, Environment, Aetiology and Sulfhydryl groupsAbstract
Geo-medicine is a multi-disciplinary field of study in Geosciences which studies the health effects of Geologic materials and processes on man, plants and creatures on earth. Such health effects can be good but mostly hazardous. It thus integrates professionals from Geology, Medicine, Pharmacy, Chemistry and Geography to handle problems accruing from the geological environment of an area. Metals can have a number of detrimental or beneficial effects in the cell, but first they must get into the body system. Nonessential metals often enter the cell through use of the machinery provided for essential goods. These metals are transported across the plasma and organelle membranes and many can bioaccumulate in the body system. Human exposure to these metals through the food, air, fossil fuel, water media have risen due to the use of these elements as industrial products as well as sources of potable aquiferous water and erosion to combat the global pandemic of climate change. Many metals like lead, arsenic, mercury cadmium, cobalt, zinc and selenium which have been diagnosed in various occupational and environmental exposures around the world results in serious morbidity and mortality, thus, posses various serious risks to public health. Metals are taken into the body via inhalation, ingestion and dermal routes, accumulates and can be stored in both soft and hard tissues. They disrupt metabolic processes by altering a number of homeostatic processes including antioxidant balance, binding to free sulfhydryl groups, competing for binding sites on a vast array of enzymes, receptors and transport proteins.
Downloads
References
Ibrahim O. Ibrahim, Lawal Moshood Oseiza, Andesikuteb Yakubu Ali, Orire Ismaila Oloyede, Abdulraheem Kehinde Kareem. Climate Change Variability and Impacts on Aquifers Performance and Groundwater Production at Akerebiata Area, Nigeria. The Progresss Publication: A Journal of Multidisciplinary Studies. 2024, Vol.5, No. 1, Pp.37-51 ISSN (Online): 2958-292X, ISSN (Print): 2958-2911 DOI: https://doi.org/10.71016/tp/tx90aa04
Ibrahim O.Ibrahim, Andesikuteb YA, Ibrahim D Bilqees-Habeeb, Jamil A Suberu, Salako LO, Abdulbariu Ibrahim. Seasonal changes of groundwater production at Enji, Offa area, traced to climate change variability and aquifer vulnerability, Nigeria. Discovery Scientific Society Publisher. 2024. Climate Change 10: e4cc1025 PP 1-13 DOI: https://doi.org/10.54905/disssi.v10i27.e4cc1025
Selinus, O., J. A. Centeno, R. B. Finkelman, P. Weistein, and E. Derbyshire. Earth and Health—building a safer environment: Planet Earth journal. 2001: 1: 1–16.
Selinus, O. and R. B. Finkelman,. Geochemical aspects of medical geology: Journal of the Geological Society of Sri Lanka. 2011. 14:1–9.
Banci L, Bertini I, Ciofi-Baffoni S, Kozyreva T, Zovo K, Palumaa P. Nature. 2010; 465: 645–648 DOI: https://doi.org/10.1038/nature09018
Selinus, O., B. Alloway, J. A. Centeno, R. B. Finkelman, R. Fuge, U. Lindh, and P. Smedley, eds. Essentials of medical geology: Amsterdam. Elsevier, 2018: 805 .
Villanueva, C.M.; Kogevinas, M.; Cordier, S.; Templeton, M.R.; Vermeulen, R.; Nuckols, J.R.; Nieuwenhuijsen, M.J.; Levallois, P. Assessing exposure and health consequences of chemicals in drinking water: Current state of knowledge and research needs. Environ. Health Perspect. 2014, 122, 213–221 DOI: https://doi.org/10.1289/ehp.1206229
Reimann, C.; Birke, M. Geochemistry of European Bottled Water; Borntraeger Science Publishers: Stuttgart, Germany, Springer: 2010: 132-146
Syracuse Research Corporation. United States. Dept. of Health and Human Services Bulletin., United States. Agency for Toxic Substances and Disease Registry and United States. Atlanta, GA: Public Health Service.
Espinoza A, Le Blanc S, Olivares M, Pizarro F, Ruz M, Arredondo M. Biol Trace Elem Res. 2011. 188-196
Voutchkova, D.D.; Ernstsen, V.; Hansen, B.; Sørensen, B.L.; Zhang, C.; Kristiansen, S.M. Assessment of spatial variation in drinking water iodine and its implications for dietary intake: A new conceptual model for Denmark. Sci. Total Environ. 2014, 493, 432–444. DOI: https://doi.org/10.1016/j.scitotenv.2014.06.008
Barnes N, Bartee MY, Braiterman L, Gupta A, Ustiyan V, Zuzel V, Kaplan JH, Hubbard AL, Lutsenko S. Traffic. 2009;10:767–779 DOI: https://doi.org/10.1111/j.1600-0854.2009.00901.x
Wildermuth E, Stark H, Friedrich G, Ebenhoch F, Kuhborth B, Silver J, Rituper R. Ullmann's Encyclopedia of Industrial Chemistry. 2000. 255-262
Monsen ER, Hallberg L, Layrisse M, Hegsted DM, Cook JD, Mertz W, Finch CA. Am J Clin Nutr. 1978;31:134–141. DOI: https://doi.org/10.1093/ajcn/31.1.134
Sendamarai AK, Ohgami RS, Fleming MD, Lawrence CM. Proc Natl Acad Sci U S A. 2008;105:7410–7415. DOI: https://doi.org/10.1073/pnas.0801318105
Touret N, Furuya W, Forbes J, Gros P, Grinstein S. J Biol Chem. 2003;278:25548–25557. DOI: https://doi.org/10.1074/jbc.M212374200
Kawabata H, Yang R, Hirama T, Vuong PT, Kawano S, Gombart AF, Koeffler HP. Journal of Biol Chem. 1999;274:20826–20832. DOI: https://doi.org/10.1074/jbc.274.30.20826
Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA. Nature. 1997;388:482–488. DOI: https://doi.org/10.1038/41343
Oudit GY, Sun H, Trivieri MG, Koch SE, Dawood F, Ackerley C, Yazdanpanah M, Wilson GJ, Schwartz A, Liu PP, Backx PH. Nat Med. 2003; 9:1187–1194. DOI: https://doi.org/10.1038/nm920
Biagioli M, Pinto M, Cesselli D, Zaninello M, Lazarevic D, Roncaglia P, Simone R, Vlachouli C, Plessy C, Bertin N, Beltrami A, Kobayashi K, Gallo V, Santoro C, Ferrer I, Rivella S, Beltrami CA, Carninci P, Raviola E, Gustincich S. Proc Natl Acad Sci U S A. 2009;106:15454–15459. DOI: https://doi.org/10.1073/pnas.0813216106
Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loreal O. Journal of Biol Chem. 2001;276:7811–7819. DOI: https://doi.org/10.1074/jbc.M008923200
Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, Grandchamp B, Sirito M, Sawadogo M, Kahn A, Vaulont S. Proc Natl Acad Sci U S A. 2002;99:4596–4601. DOI: https://doi.org/10.1073/pnas.072632499
Ding H, Yan CZ, Shi H, Zhao YS, Chang SY, Yu P, Wu WS, Zhao CY, Chang YZ, Duan XL Plos One. 2011; 6:e25324. DOI: https://doi.org/10.1371/journal.pone.0025324
Donovan A, Lima CA, Pinkus JL, Pinkus GS, Zon LI, Robine S, Andrews NC. Cell Metabrane. 2005;1:191–200. DOI: https://doi.org/10.1016/j.cmet.2005.01.003
Moos T, Rosengren Nielsen T. Semin Pediatr Neurol. 2006;13:149–157. DOI: https://doi.org/10.1016/j.spen.2006.08.003
Nemeth E, Preza GC, Jung CL, Kaplan J, Waring AJ, Ganz T. Blood. 2006;107:328–333 DOI: https://doi.org/10.1182/blood-2005-05-2049
Li L, Holscher C, Chen BB, Zhang ZF, Liu YZ. Biol Trace Elem Res. 2011;143:1581–1593. DOI: https://doi.org/10.1007/s12011-011-8967-3
Zhang DL, Hughes RM, Ollivierre-Wilson H, Ghosh MC, Rouault TA. Cell Metabolism. 2009;9:461–473. DOI: https://doi.org/10.1016/j.cmet.2009.03.006
Yang F, Liu XB, Quinones M, Melby PC, Ghio A, Haile DJ. J Biol Chem. 2002;277:39786–39791 DOI: https://doi.org/10.1074/jbc.M201485200
Ohgami RS, Campagna DR, McDonald A, Fleming MD. Blood. 2006;108:1388–1394. DOI: https://doi.org/10.1182/blood-2006-02-003681
Hentze MW, Muckenthaler MU, Galy B, Camaschella C. Cell. 2010;142:24–38. DOI: https://doi.org/10.1016/j.cell.2010.06.028
Theurl I, Schroll A, Nairz M, Seifert M, Theurl M, Sonnweber T, Kulaksiz H, Weiss G. Haematologica. 2011;96:1761–1769. DOI: https://doi.org/10.3324/haematol.2011.048926
Feder JN, Penny DM, Irrinki A, Lee VK, Lebron JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ, Schatzman RC. Proc Natl Acad Sci U S A. 1998;95:1472–1477. DOI: https://doi.org/10.1073/pnas.95.4.1472
Gunter TE, Miller LM, Gavin CE, Eliseev R, Salter J, Buntinas L, Alexandrov A, Hammond S, Gunter KK. J Neurochem. 2004; 88:266–280. DOI: https://doi.org/10.1046/j.1471-4159.2003.02122.x
Thompson K, Molina RM, Donaghey T, Schwob JE, Brain JD, Wessling-Resnick M. FASEB J. 2007;21:223–230. DOI: https://doi.org/10.1096/fj.06-6710com
Burdo JR, Menzies SL, Simpson IA, Garrick LM, Garrick MD, Dolan KG, Haile DJ, Beard JL, Connor JR. Journal of Neurosci Res. 2001;66:1198–1207. DOI: https://doi.org/10.1002/jnr.1256
van den Berghe PV, Folmer DE, Malingre HE, van Beurden E, Klomp AE, van de Sluis B, Merkx M, Berger R, Klomp LW. Biochem Journal. 2007;407:49–59. DOI: https://doi.org/10.1042/BJ20070705
Riccio A, Mattei C, Kelsell RE, Medhurst AD, Calver AR, Randall AD, Davis JB, Benham CD, Pangalos MN. Journal Biol Chem. 2002; 277:12302–12309. DOI: https://doi.org/10.1074/jbc.M112313200
Crossgrove JS, Allen DD, Bukaveckas BL, Rhineheimer SS, Yokel RA. Neurotoxicology. 2003; 24:3–13. DOI: https://doi.org/10.1016/S0161-813X(02)00089-X
He L, Girijashanker K, Dalton TP, Reed J, Li H, Soleimani M, Nebert DW. Mol Pharmacol. 2006;70:171–180. DOI: https://doi.org/10.1124/mol.106.024521
Girijashanker K, He L, Soleimani M, Reed JM, Li H, Liu Z, Wang B, Dalton TP, Nebert DW. Mol Pharmacol. 2008;73:1413–1423. DOI: https://doi.org/10.1124/mol.107.043588
Gitler AD, Chesi A, Geddie ML, Strathearn KE, Hamamichi S, Hill KJ, Caldwell KA, Caldwell GA, Cooper AA, Rochet JC, Lindquist S. Nat Genet. 2009; 41:308–315. DOI: https://doi.org/10.1038/ng.300
Yin Z, Jiang H, Lee ES, Ni M, Erikson KM, Milatovic D, Bowman AB, Aschner M. J Neurochem. 2010; 112:1190–1198. DOI: https://doi.org/10.1111/j.1471-4159.2009.06534.x
Pinilla-Tenas JJ, Sparkman BK, Shawki A, Illing AC, Mitchell CJ, Zhao N, Liuzzi JP, Cousins RJ, Knutson MD, Mackenzie B. Am J Physiol Cell Physiology. 2011;301:C862–C871. DOI: https://doi.org/10.1152/ajpcell.00479.2010
Cole TB, Wenzel HJ, Kafer KE, Schwartzkroin PA, Palmiter RD. Proc Natl Acad Sci U S A. 1999;96:1716–1721. DOI: https://doi.org/10.1073/pnas.96.4.1716
Palmiter RD, Cole TB, Quaife CJ, Findley SD. Proc Natl Acad Sci U S A. 1996;93:14934–14939. DOI: https://doi.org/10.1073/pnas.93.25.14934
Sensi SL, Yin HZ, Carriedo SG, Rao SS, Weiss JH. Proc Natl Acad Sci U S A. 1999; 96:2414–2419. DOI: https://doi.org/10.1073/pnas.96.5.2414
Gruenheid S, Canonne-Hergaux F, Gauthier S, Hackam DJ, Grinstein S, Gros P. Journal of Exp Med. 1999; 189:831–841 DOI: https://doi.org/10.1084/jem.189.5.831
Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, Yoshimura MP, Berger C, Chan PH, Wallace DC, Epstein CJ. Nat Genet. 1995;11:376–381. DOI: https://doi.org/10.1038/ng1295-376
Milatovic D, Zaja-Milatovic S, Gupta RC, Yu Y, Aschner M. Toxicol Appl Pharmacol. 2009;240:219–225. DOI: https://doi.org/10.1016/j.taap.2009.07.004
Stredrick DL, Stokes AH, Worst TJ, Freeman WM, Johnson EA, Lash LH, Aschner M, Vrana KE. Neurotoxicology. 2004; 25:543–553 DOI: https://doi.org/10.1016/j.neuro.2003.08.006
Stredrick DL, Stokes AH, Worst TJ, Freeman WM, Johnson EA, Lash LH, Aschner M, Vrana KE. Neurotoxicology. 2004; 25:543–553 DOI: https://doi.org/10.1016/j.neuro.2003.08.006
Estevez AG, Crow JP, Sampson JB, Reiter C, Zhuang Y, Richardson GJ, Tarpey MM, Barbeito L, Beckman JS. Science. 1999; 286:2498–2500 DOI: https://doi.org/10.1126/science.286.5449.2498
Robbins AH, McRee DE, Williamson M, Collett SA, Xuong NH, Furey WF, Wang BC, Stout CD. Public Health and Elements. Journal of Mol Biol. 1991; 221:1269–1293 DOI: https://doi.org/10.1016/0022-2836(91)90933-W
Yoshino Y, Yuan B, Kaise T, Takeichi M, Tanaka S, Hirano T, Kroetz DL, Toyoda H. Toxicolology. Journal of Applied Pharmacol. 2011; 257:198–208. DOI: https://doi.org/10.1016/j.taap.2011.09.006
Ishibashi K, Kuwahara M, Kageyama Y, Tohsaka A, Marumo F, Sasaki S. Biochem Biophys Res Commun. 1997; 237:714–718. DOI: https://doi.org/10.1006/bbrc.1997.7219
Campbell, N.; Dary, O.; Cappuccio, F.P.; Neufeld, L.M.; Harding, K.B.; Zimmermanne, M.B. Collaboration to optimize dietary intakes of salt and iodine: A critical but overlooked public Health issue. Bull. World Health Organ. 2012, 90, 73–74. DOI: https://doi.org/10.2471/BLT.11.092080
Fuge, R. Soils and Iodine Deficiency. In Essentials of Medical Geology: Impacts of the Natural Environment on Public Health; Selinus, O., Alloway, B.J., Centeno, J.A., Finkelman, R.B., Fuge, R., Lindh, U., Smedley, P., Eds.; Elsevier: Amsterdam, The Netherlands, 2005: 417–433.
Liu Z, Sanchez MA, Jiang X, Boles E, Landfear SM, Rosen BP. Biochem Biophys Res Commun. 2006: 351:424–430. DOI: https://doi.org/10.1016/j.bbrc.2006.10.054
Bradman A, Eskenazi B, Sutton P, Athanasoulis M, Goldman LR. Environ Health Perspect. 2001: 109:1079–1084. DOI: https://doi.org/10.1289/ehp.011091079
Gu C, Chen S, Xu X, Zheng L, Li Y, Wu K, Liu J, Qi Z, Han D, Chen G, Huo X. Neurochem Res. 2009; 34:1150–1156 DOI: https://doi.org/10.1007/s11064-008-9891-6
D’Acremont V, Kilowoko M, Kyungu E, Philipina S, Sangu W, Kahama-Maro J et al (2014). Beyond malaria-causes of fever in outpatient Tanzanian children. N Engl J Med 370:809–817 DOI: https://doi.org/10.1056/NEJMoa1214482
World Health Organisation (WHO) (2018) Cancer. https:// www. who. int/ news- room/ fact- sheets/ detail/ cancer. Accessed 11 Dec 2020
Jagannatha Rao KS, Ranganath Rao V, Shanmugavelu P, Menon RB (2018). Trace elements in Alzheimer’s Disease brain: a new hypothesis. In Alzheimer’s disease brain: a new hypothesis. Alzheimer’s Rep 2(4):211–216
Hoffman K, Weisskopf MG, Roberts AL, Raz R, Hart JE, Lyall K, Hoffman EM, Laden F, Vieira VM (2017). Geographic patterns of autism spectrum disorder among children of participants in nurses’ health study II. Am J Epidemiol 186(7):834–842. https:// doi. org/ 10. 1093/ aje/ kwx158 DOI: https://doi.org/10.1093/aje/kwx158
Downloads
Published
Issue
Section
License
Copyright (c) 2025 International Journal of Scientific Research in Science and Technology

This work is licensed under a Creative Commons Attribution 4.0 International License.
https://creativecommons.org/licenses/by/4.0