The Potential of Stem Cell Therapy in Regenerative Medicine and Injury Recovery
DOI:
https://doi.org/10.32628/IJSRST25121190Keywords:
Mesenchymal Stem Cells, Exosomes, Wound Healing, Regenerative Medicine, Immune ModulationAbstract
Synthetic molecules derived from mesenchymal stem cells (MSCs) and from MSC-derived exosomes show promise as regenerative potential for tissue repair and wound healing. MSCs are multipotent and can differentiate into different cell types, the effect of which is enhanced through exosomes, via paracrine signalling. Guillamat-Prats (2021) concludes recent studies have shown that MSCs can accelerate wound healing by up to 50% compared to control groups, and that MSC derived exosomes have doubled cellular migration and collagen deposition in vitro. Additionally, MSC therapies have been able to dramatically decrease inflammatory cytokines like TNFα and IL6 by up to 40%, leading to a more environmentally favorable healing milieu (Lee et al., 2023). The aim of this study is to investigate the effects of MSC and MSC derived exosome treatments on wound healing, specifically enhanced regenerative properties and immune modulation of MSC exosomes. Although results were subjective, histological analysis showed that the highest improvement in wound closure was achieved with MSC+Exosome treatments, which healed over 95% after 14 days, while control groups healed 60%. Finally, the study demonstrates the utility of exosome based delivery systems for targeted, efficient and off target effect free tissue repair. The results are encouraging, but there are still challenges, including scalability and immune rejection, and future research will be aimed at improving the isolation of exosomes and studying MSC based therapies for chronic wound management, cartilage regeneration and neurodegenerative disease.
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