Isolation and Extraction of as Ferulic Acid from Medicinally Active Andrographis Paniculata Plant and Synthesis of its Analogues

Authors

  • N. R. Nahate Department of Chemistry, Shri R. R. Lahoti Science College, Morshi, Dist. Amravati, 444 905, Maharashtra, India Author
  • Abdul Wajid Department of Chemistry, Shri Shivaji Arts, Commerce and Science College, Akot Dist. Akola 444101, Maharashtra, India Author
  • C. A. Ladole Department of Chemistry, Shri Shivaji Arts, Commerce and Science College, Akot Dist. Akola 444101, Maharashtra, India Author

DOI:

https://doi.org/10.32628/IJSRST2512131

Keywords:

Ferulic acid, antioxidant, isolation, extraction

Abstract

Ferulic acid has been shown to have biological activities such as antimicrobial, antioxidant, anti-inflammatory, anti-thrombogenic and anticancer properties. Moreover, it decreases liver and serum cholesterol, increases sperm viability, and all of these advantages are advantageous for coronary heart disease. Apart from this, it exhibits great commercial potential in the food, health and cosmetic industries. Because ferulic acid is absorbed and metabolized by the human body, it has additional advantages. Thus, devised a plan to extract and isolate ferulic acid from Andrographis Paniculata based on the aforementioned features. Based on the properties of this, we have strategies to isolate the ferulic acid and synthesis of their analogues like ester and amide. Which were characterized by 1HNMR and GCMS.

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References

Mota, F. L., Queimada, A. J., Pinho, S. P., & Macedo, E. A. Industrial & Engineering Chemistry Research, 47(15), 5182-5189, (2008). DOI: https://doi.org/10.1021/ie071452o

de Oliveira, D. M., Finger‐Teixeira, A., Rodrigues Mota, T., Salvador, V. H., Moreira‐Vilar, F. C., Correa Molinari, H. B., & Dantas dos Santos, W. Plant biotechnology journal, 13(9), 1224-1232, (2015). DOI: https://doi.org/10.1111/pbi.12292

Zhao, Z., & Moghadasian, M. H. Food Chemistry, 109(4), 691-702, (2008). DOI: https://doi.org/10.1016/j.foodchem.2008.02.039

Kumar, N., & Pruthi, V. Biotechnology Reports, 4, 86-93, (2014). DOI: https://doi.org/10.1016/j.btre.2014.09.002

Bagchi, D., Moriyama, H., & Swaroop, A. Green coffee bean extract in human health. CRC Press, (2016). DOI: https://doi.org/10.1201/9781315371153

Gelinas, P., & McKinnon, C. M. International journal of food science & technology, 41(3), (2006). DOI: https://doi.org/10.1111/j.1365-2621.2005.01057.x

Beejmohun, V., Fliniaux, O., Grand, É., Lamblin, F., Bensaddek, L., Christen, P., & Mesnard, F. Phytochemical Analysis: An International Journal of Plant Chemical and Biochemical Techniques, 18(4), 275-282, (2007). DOI: https://doi.org/10.1002/pca.973

Quinde-Axtell, Z., & Baik, B. K., Journal of agricultural and food chemistry, 54(26), 9978-9984, (2006). DOI: https://doi.org/10.1021/jf060974w

Luthria, D. L., & Pastor-Corrales, M. A. P. Journal of food composition and analysis, 19(2-3), 205-211, (2006). DOI: https://doi.org/10.1016/j.jfca.2005.09.003

Anson, N. M., van den Berg, R., Havenaar, R., Bast, A., & Haenen, G. R. Journal of Cereal Science, 49(2), 296-300, (2009). DOI: https://doi.org/10.1016/j.jcs.2008.12.001

Buanafina, M. Mol. Plant, 2, 861–872, (2009). DOI: https://doi.org/10.1093/mp/ssp067

Dyk, J.S.V. and Pletschke, B.I. Biotechnol. Adv. 30,1458–1480, (2012). DOI: https://doi.org/10.1016/j.biotechadv.2012.03.002

Escobar, J., Lora, E., Venturini, O., Yanez, E., Castillo, E. and Almazan, O. Renew. Sustain. EnergyRev. 13, 1275–1287, (2009). DOI: https://doi.org/10.1016/j.rser.2008.08.014

Franke, R., Humphreys, J.M., Hemm, M.R., Denault, J.W., Ruegger, M.O., Cusumano, J.C. and Chapple, C. Plant J. 30, 33–45, (2002). DOI: https://doi.org/10.1046/j.1365-313X.2002.01266.x

Fry, S. Annu. Rev. Plant Physiol. 37, 165–186, (1986). DOI: https://doi.org/10.1146/annurev.pp.37.060186.001121

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Published

03-02-2025

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Research Articles