Green and Efficient Synthesis of Novel Pyrazole based Hydrazineyl-Thiazole Derivatives
DOI:
https://doi.org/10.32628/IJSRST25122220Keywords:
Green synthesis, Pyrazole, p-TSA, hydrazineyl-thiazolesAbstract
A green and efficient protocol for the synthesis of novel pyrazole based hydrazineyl-thiazole derivatives via a two-step procedure is reported. The reaction has been catalyzed by p-TSA using ethanol as green solvent. The present protocol offers several advantages such as broad substrate scope, operational simplicity, high yields and use of environmentally benign solvent.
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References
E. Kabir and M. Uzzaman, A review on biological and medicinal impact of heterocyclic compounds. Results in Chemistry, 4, 100606, (2021).
B. P. Bandgar, S. S. Makone, S. R. Kulkarni, Microwave Induced Synthesis of Geminal Diacetates from Aldehydes Using Envirocat EPZ10® Without Solvent, Monatsh. Chem.,131, 417-420, (2000).
D. M. Pore, T. S. Shaikh, N. G. Patil, S. B. Dongare, U. V. Desai, Envirocat EPZ-10: A solid acid catalyst for the synthesis of 1, 8-dioxo-octahydroxanthenes in aqueous medium, Syn. Comm., 40, 2215-2219, (2010).
P. M. Mhaldar, D. M. Pore, Envirocat EPZ-10: An Efficient Catalyst for the Synthesis of 1, 2, 4-Triazolidine-3-thiones, Letters in Organic Chemistry, 17(4), 321-326, (2020).
O. S. Chavan, S. A. Jadhav, M. G. Shioorkar, S. B. Chavan, M. A. Baseer, Mild and Efficient one pot synthesis of bis (4-hydroxy coumarins) derivatives using EPZ-10 catalyst at room temperature by simple grinding technique, Chemical Science Review and Letters, 4(16), 945-949, (2015).
T. S. Shaikh, K. A. Undale, D. S. Gaikwad, D. M. Pore, Envirocat EPZ-10: An efficient catalyst for the synthesis of 3-acetoacetylcoumarins, Comptes Rendus Chimie, 14(11), 987-990, (2011).
D. M. Pore, T. S. Shaikh, N. G. Patil, S. B. Dongare, U. V. Desai, Envirocat EPZ-10: A solid acid catalyst for the synthesis of 1, 8-dioxo-octahydroxanthenes in aqueous medium Synthetic Communications, 40(15), 2215-2219, (2010).
O. B. Pawar, F. R.Chavan, N. D. Shinde, EPZ 10 as a reusable heterogeneous catalyst for the synthesis of coumarins, Organic Chemistry: An Indian Journal, 5(4), 449-451, (2009).
Lee, Key-Young; Ko, Kwang-Youn, Envirocat EPZ10: A Recyclable Solid Acid Catalyst for the Synthesis of Biginelli-type 3,4-Dihydropyrimidin-2(1H)-onesBulletin of the Korean Chemical Society, 25(12), 1929-1931, (2004).
V. A. Mahajan, P. D. Shinde, A. S. Gajare, M. Karthikeyan, R. D. Wakharkar, EPZ-10 catalyzed regioselective transformation of alkenes into β-iodo ethers, iodohydrins and 2-iodomethyl-2,3-dihydrobenzofurans, Green Chemistry, 4(4), 325-327, (2002).
B. P. Bandgar, S. P. Kasture, Envirocats, as Novel Solid-Supported Catalysts for Friedel-Crafts Acylation, Journal of the Chinese Chemical Society (Taipei), 47(6), 1243-1246, (2000).
B. P. Bandgar, S. P. Kasture, Environmentally Friendly Arylmethylation of Aromatics with Benzyl Halides Using Envirocat EPZ10® as the Catalyst, Monatshefte fuer Chemie, 131(8), 913-915, (2000).
A. S. Gajare, M. S. Shingare, B. P. Bandgar, Selective Transdithio acetalization of Acetals, Ketals, Oxathioacetals and Oxathioketals Catalyzed by Envirocat EPZ10, Journal of Chemical Research, Synopses, (8), 452-453, (1998)
B. Baghernejad, Application of p-toluenesulfonic acid (PTSA) in organic synthesis, Curr. Org. Chem. 15, 3091–3097, (2011).
S. H. Sukanya, T. Venkatesh, S. J. Aditya Rao, A. Pandith, An efficient p-TSA catalyzed synthesis of some new substituted-(5-hydroxy-3-phenylisoxazol-4-yl)-1,3-dimethyl-1H-chromeno [2,3-d]pyrimidine-2,4(3H,5H)-dione/3,3dimethyl-2Hxanthen-1(9H)-one scaffolds and evaluation of their pharmacological and computational investigations, J. Mol. Struct. 1267, 133587, (2022).
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