Synthesis of Novel Vanillic Acid Hybrid Derivative
DOI:
https://doi.org/10.32628/IJSRST25122221Keywords:
Vanillic acid, IR, 1HNMR, TOF MS, DCC, DMAP, antibacterial, Gram +ve and Gram -veAbstract
Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is a dihydroxybenzoic acid derivative used as a flavoring agent. It is used in the synthesis of various active pharmaceutical ingredients such as Etamivan, Modecainide, Brovanexine, Vanitiolide, Vanyldisulfamide etc. In this paper, novel ester / hybrid derivative of vanillic acid was synthesized. This combinatorial synthesis of novel vanallic ester / hybrid derivative can be a useful approach to generate potent chemotherapeutic agents in developing new drug candidates.
Downloads
References
Wattenberg L. W., Coccia J. B. and Lam L. K. Inhibitory effects of phenolic compounds on benzo[a]pyrene induced neoplasia. Cancer Res. 1980, 40 : 2820 – 2823.
Talalay P, De Long M. J. and Prochaska H. J. Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogens. Proc. Natl. Acad. Sci. 1988, 85 : 8261 – 8265.
Macheix J. J., Fleuriet A. and Billot J. Fruit phenolics. CRC press Inc., Boca Raton 1990, FL.
Natarajan K, Singh S, Burke T. R. Jr., Grunberger D. and Aggarwal B. B. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc. Natl. Acad. Sci. 1996, 93 : 9090 – 9095.
Chiao C., Carothers A. M., Grunberger D., Solomon G., Preston G. A. and Barrett J. C. Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells. Cancer Res. 1995, 55 : 3576 – 3583.
Burke T. R. Jr, Fesen M. R., Mazumder A., Wang J., Carothers A. M., Grunberger D., Driscoll J., Kohn K. and Pommier Y. Hydroxylated aromatic inhibitors of HIV-1 integrase. J. Med. Chem. 1995, 38 (21) : 4171 – 4178.
Bose J. S., Gangan V. D., Jain S. K. and Manna S. K. Novel caffeic acid ester derivative induces apoptosis by expressing FasL and downregulating NFKappaB : Potentiation of cell death mediated by chemotherapeutic agents. J. Cell Physiol. 2009, 218 (3) : 653 – 662.
Bose J. S., Gangan V. D., Jain S. K. and Manna S. K. Downregulation of inflammatory responses by novel caffeine acid ester derivative by inhibiting NF kappaB. Journal of Clinical Immunology 2009, 29, pp. 90 - 98.
Bose J. S., Gangan V. D. (2007). Applied for US patent on “NOVEL CHEMOTHERAPEUTIC AGENTS AGAINST INFLAMMATION AND CANCER” from Reliance Life Sciences [INDIA 1696/MUM/2006, Publication No. WO/2008/062466, [International Application No. PCT/IN2007/000488].
Satpute M. S., Shastri, I. and Gangan V. D. (2018); International Journal for Research in Applied Science & Engineering Technology, 6 (XII), pp. 330 - 334.
Satpute M. S., Shastri, I. and Gangan V. D. International Journal of Scientific Research in Science and Technology 2018, 4 (11), pp. 219 - 223.
a ) Finn R. K. Theory of Agar Diffussion Methods for Bioassay. Anal. Chem., 1959, 31 (6), pp 975 – 977. b ) Al lafi T et. al.. The effect of miswak used in Jordan and Middle East on oral bacteria. International Dental Journal, 1995, 45 (3), pp. 218 – 222.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 International Journal of Scientific Research in Science and Technology

This work is licensed under a Creative Commons Attribution 4.0 International License.