A Comprehensive Review on Pharmacological Properties of Tectona Grandis. Linn
DOI:
https://doi.org/10.32628/IJSRST251222617Keywords:
Tectona grandis, Antidiabetic, Hair growth, Cytotoxic, Nanoparticle, Bioactive PhytoconstituentsAbstract
Tectona grandis is a huge deciduous tree that is found throughout Myanmar Southeast Asia, and the Indian subcontinent and is a member of the Lamiaceae family. Traditionally, various parts of the plant, including its root, seed, flowers, leaves, and bark, have been used in folk medicine for treating ailments such as ulcers, diabetes, inflammation, skin disorders, and microbial infections. The phytochemical composition of Tectona grandis is highly diverse, encompassing naphthoquinones, anthraquinones, flavonoids, terpenoids, alkaloids, phenolic acids, and saponins, which are responsible for its extensive pharmacological properties. This review compiles and critically analyzes the therapeutic potential of Tectona grandis, focusing on its anti-ulcerogenic, cytotoxic, antihyperglycemic, antifungal, antioxidant, antimicrobial, antiasthmatic, anticonvulsant, analgesic, and diuretic activities. Additionally, its role in hair growth stimulation and nutritional benefits is discussed. Furthermore, recent advancements in the synthesis of metal nanoparticles from Tectona grandis extracts have demonstrated promising applications in antimicrobial and cytotoxic therapies.
Downloads
References
Lukmandaru G., Takahashi K., Radial distribution of quinones in plantation teak (Tectona grandis Lf). An. For. Sci. 66 (2009) 1.
Budianto P., Suroto S., Wasita B., Mirawati D.K, "Tectona Grandis Leaves: Determination of Total Flavonoid Content, Phenolic Content, Characterization of the Leaves, and Compound Identification in GC-MS." Pharmacogn. J. 15 (2023).
Devi D.A., Prabhu A, A Critical Literary Review of Shaka/Teak (Tectona Grandis Linn) and the Pharmacognosy of Shaka Pushpa Int. J. Ayurvedic Herb. Med. 11 (2021) 4097.
Vyas P., Yadav D.K., Khandelwal P., "Tectona grandis (teak)–A review on its phytochemical and therapeutic potential." Nat. Prod. Res. 33 (2019) 2338.
Krishna M.S., Jayakumaran N.A., "Antibacterial, cytotoxic and antioxidant potential of different extracts from leaf, bark and wood of Tectona grandis." Int. J. Pharm. Sci. Drug Res. 2 (2010) 155.
Kolli P.K., Obbalareddy S., Yejella R.P., Athili L.D., Ponnada S., "A REVIEW ON TECTONA GRANDIS." Int. J. Res. Pharm. Chem. 12 (2022) 359.
Asdaq S.M.B., Nayeem N., Alam M.T., Alaqel S.I., Imran M., Hassan E.E., Rabbani, "Tectona grandis Lf: A comprehensive review on its patents, chemical constituents, and biological activities." S.I., Saudi J. Biol. Sci. 29 (2022) 1456.
Nwaeze K.U., Ayoola G.O., Anyakora C.A., Oparah B., Chiedu D., Shode F.O., Odhav B., Smith P., "Phytochemical Screening, Antioxidant and Antiplasmodial Activities of methanol and n-hexane extracts from Stem Bark of Tectona grandis (Lamiaceae)." Niger, J. Pharm. Appl. Sci. Res. 7 (2018) 67.
Khera N., Bhargava S., "Phytochemical and pharmacological evaluation of Tectona grandis Linn."Int. J. Pharm. Pharm. Sci. 5 (2013) 923.
Rani G.J., Bhavani N.L., "Phytochemical investigation and Antipyretic activity of Tectona grandis Linn." Res. J. Pharm. Technol. 14 (2021) 4221
Joshi P., "Chemical components of the roots of Tectona grandis and Gmelina arborea." Planta Med. 32 (1977) 71.
Marques L.B., Flaviano M., Mauro P., Juliana R., Sousa F.S., Ricardo W., Lapachol acetylglycosylation enhances its cytotoxic and pro-apoptotic activities in HL60 cells, Toxicol. In Vitro 65 (2020) 104772.
Esteves-Souza A., Figueiredo D.V., Esteves A., Câmara C.A., Vargas M.D., Pinto A.C., Echevarria A., "Cytotoxic and DNA-topoisomerase effects of lapachol amine derivatives and interactions with DNA." Braz. J. Med. Biol. Res. 40 (2007) 1399.
Laskar S., Ghosh-Majumdar S., Basak B., Maity C.R., "Influence of teak (Tectona grandis; family: Verbenaceae) seed protein on some enzymes and liver lipids of albino rats." Rev. Esp. Fisiol. 41 (1985) 331.
Singh N., Kaushal K., "Pharmacological, and Phytochemical Profile of Tectona grandis linn (Verbenaceae)–A Comprehensive Review." Int. j. pharm. Sci. 5 (2024) 24.
Nidavani R.B., Mahalakshmi A.M., "Teak (Tectona grandis Linn.): A renowned timber plant with potential medicinal values Int. J. Pharm. Pharm. Sci. 6 (2004) 48.
Ramachandran S., Aiyalu R., K.K"Antidiabetic, antihyperlipidemic and antioxidant potential of methanol extract of Tectona grandis flowers in streptozotocin induced diabetic rats." Asi. Pac. J. Trop. Med. 4 (2011) 624.
Mishra B., Kar D.M., Maharana L., Dash S., Mishra G.P., "Hypoglycemic activity of methanol fraction of Tectona grandis (Linn) bark in experimental rat models." Res. J. Pharm. Technol. 14 (2021) 4247.
Ghaisas M.M., Navghare V.V., Takawale A.R., Zope V.S., Phanse M.A., "Antidiabetic and nephroprotective effect of Tectona grandis Linn. in alloxan induced diabetes." Ori. Pharm. Ex. Med. 10. (2010) 59-65.
Sharma V., Samanta K.C., "Hypoglycemic activity of methanolic extract of Tectona grandis linn. Root in alloxan induced diabetic rats." J. Appl. Pharm. Sci. (2011) 106.
Sanni O., Nkomozepi P., Islam M.S.,"Ethyl acetate fractions of tectona grandis crude extract modulate glucose absorption and uptake as well as antihyperglycemic potential in fructose–streptozotocin-induced diabetic rats." Int. J. Mol. Sci. 25 (2023) 28.
Ghaisas M.M., Navghare V.V., Takawale A.R., Zope V.S., Deshpande A.D., "In vitro antioxidant activity of Tectona grandis Linn." Pharm. 3 Ars. Pharm. 51 (2008) 296.
Asif M., "In vivo analgesic and antiinflammatory effects of Tectona grandis Linn. stem bark extracts." Mal. J. Pharm. Sci. 9 (2011) 1.
Insumrong K., Ingkaninan K., Waranuch N., Tanuphol N., Wisuitiprot W., Promgool T., Suphrom N., "Isolation and HPLC quantitative determination of 5α-reductase inhibitors from Tectona grandis Lf Leaf extract." Mol. 27 (2022) 2893.
Shukla N., Kumar M., Ahmad G., Rahuja N., Singh A.B., Srivastava A.K., Rajendran S.M., Maurya R., "Tectone, a new antihyperglycemic anthraquinone from Tectona grandis leaves." Nat. Prod. Commun. Int. j. pharm. Sci. 3 (2010) 150
Ghareeb M.A., Hussein A.H., Hassan M.F.M., Laila A.R., Mona A.M., Amal M.S., "Antioxidant and cytotoxic activities of Tectona grandis Linn leaves."Int. J. Phytopharm. 5 (2014) 143.
Murukan G., Murugan K., "Comparison of phenolic acids and antioxidant activities of young and mature leaves of Tectona grandis L F." Asian J. Pharm. Clin. Res. 11 (2018) 160.
Nayeem N., Karvekar M.D., "Antimicrobial and anti-oxidant properties of the isolated compounds from the methanolic extract from the leaves of Tectona grandis." J. Basic Clin. Pharm. 2 (2011) 163.
Goswami D., Nirmal S., Patil M., Dighe N., Laware R., Pattan S., "An overview of Tectona grandis: chemistry and pharmacological profile."Pharm. Rev. 3 (2009) 181.
Rawal V.P., Patil L.P., "Anticonvulsant activity of Tectona grandis Linn bark extracts." Pharma Sci. Monit. 8 (2017) 23
Sharma G., Tiwari S.B., Singh S.D., (Anxiolytic and anticonvulsant evaluation of methanolic extract of Tectona grandis bark). Eur. Chem. Bull. 2023, 12, (2023) 1317 – 1327
Rautela A., Rani J.,"Green synthesis of silver nanoparticles from Tectona grandis seeds extract: characterization and mechanism of antimicrobial action on different microorganisms." J. Anal. Sci. Tech. 10 (2019) 1.
Senthilkumar N., Nandhakumar E., Priya P., Soni D., Vimalan M., Potheher I.V., "Synthesis of ZnO nanoparticles using leaf extract of Tectona grandis (L.) and their anti-bacterial, anti-arthritic, anti-oxidant and in vitro cytotoxicity activities." New J. Chem. 41 (2017) 10347.
Younis H.M., Hussein H.A., Khaphi F.L., Saeed Z.K., "Green biosynthesis of silver and gold nanoparticles using Teak (Tectona grandis) leaf extract and its anticancer and antimicrobial activity." Heliyon 9 (2023) 11.
Maishera H.A., Kuta F.A., Tijani J.O., Adabara N.U., Adedeji A.S., Bala J.D., "Biosynthesis and antibacterial potential of tectona grandis mediated magnesium oxide nanorods." J. Biosci. 27 (2019) 109.
Krishna M.S., "Antibacterial, cytotoxic and antioxidant potential of different extracts from leaf, bark and wood of Tectona grandis." Jayakumaran N.A., Int. J. Pharm. Sci. Drug Res. 2 (2010) 155.
Neamatallah A., Yan L., Dewar S.J., Austin B., "An extract from teak (Tectona grandis) bark inhibited Listeria monocytogenes and methicillin resistant Staphylococcus aureus." Lett. Appl. Microbiol. 41 (2005) 94.
Danlami U., Simon O., "A Comparative Study on the Phytochemicals and Antimicrobial Activities of the Hexane Extracts of the Leaves of Tectona Grandis and Its Mistletoe." Am. J. Heterocyclic Chem. 3 (2017) 19.
Javalgikar A., Shaikh H., Sargar M., Survanshi H., Rathod M., "In Vitro Anti-Inflammatory and Anthelmintic Activity of Tectona grandis Leaves Extract,”. Int. J. Herb. Med. 7 (2019) 26.
Chen X., Ni J., Zhang K., Zhao X., Zhang Y., "Antidiabetic effects of two naphthoquinones from the branches and leaves of Tectona grandis and possible mechanism." Fitoterapia 396 (2025) 106
Krishna M.S., Jayakumaran N.A., “Antibacterial, cytotoxic and antioxidant potential of different extracts from leaf, bark and wood of Tectona grandis.’’ Int. J. Pharm. Sci. Drug Res. 2 (2010) 155.
Rao K.N.V., Aradhana R., Banjii D.B., Chaitanya R.S.N.A.K.K., Kumar A.A., (In-vitro antioxidant and free radical scavenging activity of various extracts of Tectona grandis Linn leaves). J. of pharm. Res. (2011).
Giri S.P., Varma S.B., “Analgesic and anti-inflammatory activity of Tectona grandis Linn. stem extract’’ J. Basic Clin. Physiol. Pharmacol. 26 (2015) 479.
Khan R.M., Mlungwana S.M., Phytochemistry. 5-Hydroxylapachol: a cytotoxic agent from Tectona grandis. Int. j. 50 (1999) 439.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 International Journal of Scientific Research in Science and Technology

This work is licensed under a Creative Commons Attribution 4.0 International License.