Effect of Rota Plant Extracts on the SIRT3 Sertoin-3 Concentration in the Alzheimer Patients' Blood
DOI:
https://doi.org/10.32628/IJSRST5241126Keywords:
Ruta Plant, Alzheimer's Disease, Sirtuin3, Flavonoid, Preparation Of Plant ExtractsAbstract
We induced Alzheimer's disease in a group of mices, after which they were treated with extracts of the Ruta plant, which included a group of chemical compounds, including alkaloids, flavonoids, and the oil extract. The results of treatment with the Ruta plant extract showed a significant effect on the biochemical variables studied, as the Ruta extracts led to raising the concentration of the sirtuin3 enzyme to good levels with a significant difference from the affected group. As for the flavonoid extract, it was the most efficient by recording the lowest average of the enzyme between the groups. Infected.
📊 Article Downloads
References
Asif, M. (2015). Chemistry and antioxidant activity of plants containing some phenolic compounds. Chemistry international, 1(1), 35-52.
Sisein, E. A. (2014). Biochemistry of free radicals and antioxidants. Scholars Academic Journal of Biosciences, 2(2), 110-118.
Ugbabe Grace, E., Aliyu, A., Okhale Samuel, E., & Igura Paul, A. (2019). Comparative studies of essential oil of fruit peels of four citrus species (family: Rutaceae) in Nigeria. IJCS, 7(6), 2742-7.
Chooi, O. H. (1994). The ethnobotnay of citrus and their relatives. Korean Journal of Plant Taxonomy, 24(3), 157-171.
Nahar, L., El-Seedi, H. R., Khalifa, S. A., Mohammadhosseini, M., & Sarker, S. D. (2021). Ruta essential oils: Composition and bioactivities. Molecules, 26(16), 4766.
Coimbra, A. T., Ferreira, S., & Duarte, A. P. (2020). Genus Ruta: A natural source of high value products with biological and pharmacological properties. Journal of ethnopharmacology, 260, 113076.
Nogueiras, R., Habegger, K. M., Chaudhary, N., Finan, B., Banks, A. S., Dietrich, M. O., ... & Tschöp, M. H. (2012). Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiological reviews, 92(3), 1479-1514.
Chen, Y. L., Fu, L. L., Wen, X., Wang, X. Y., Liu, J., Cheng, Y., & Huang, J. (2014). Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer. Cell death & disease, 5(2), e1047-e1047.
Yin, J., Han, P., Song, M., Nielsen, M., Beach, T. G., Serrano, G. E., ... & Shi, J. (2018). Amyloid-β increases tau by mediating sirtuin 3 in Alzheimer’s disease. Molecular neurobiology, 55, 8592-8601.
Chen, Y., Fu, L. L., Wen, X., Wang, X. Y., Liu, J., & Cheng, Y. (2014). Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer. Cell Death Dis. 2014; 5: e1047.
Cheng, A., Wang, J., Ghena, N., Zhao, Q., Perone, I., King, T. M., ... & Mattson, M. P. (2020). SIRT3 haploinsufficiency aggravates loss of GABAergic interneurons and neuronal network hyperexcitability in an Alzheimer's disease model. Journal of Neuroscience, 40(3), 694-709.
Khanna, A., Acharjee, P., Acharjee, A., & Trigun, S. K. (2019). Mitochondrial SIRT3 and neurodegenerative brain disorders. Journal of chemical neuroanatomy, 95, 43-53.
Fetit, R. (2023). Celebrating the life and research of BNA Past-President Colin Blakemore. Brain and Neuroscience Advances, 7, 23982128231195514.
ALİ, A. M., ALSAQA, R., & SULTAN, N. S. (2022). Study of Thermodynamic Properties of Monoclinic Sulfur (Sβ) Under High Pressure Using Three Different Equations of State for the Treatment Scabies in Dermatology. International Journal of Thermodynamics, 25(2), 33-38. https://doi.org/10.5541/ijot.1003950.
R. H. Al-saqa, I. K. Jassim. 2023. “Effect of KOH Concentration on the Optical and Structural Properties of Perovskite CaZnO3 Thin Films.” International Journal of Scientific Research in Science and Technology 10(1): 33– 37. DOI: 10.32628/IJSRST229692.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 International Journal of Scientific Research in Science and Technology
This work is licensed under a Creative Commons Attribution 4.0 International License.
https://creativecommons.org/licenses/by/4.0
